Results 181 to 190 of about 1,985,761 (312)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Reversing the great degradation of nature by reducing factors related to cropland expansion. [PDF]

Proc Natl Acad Sci U S A
Polasky S, Nelson E, Tilman D, Gerber J, Johnson JA, Corong E, Isbell F, Hill J, Packer C.   +8 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Quasi-monoenergetic deuteron acceleration via boosted coulomb explosion by reflected picosecond laser pulse. [PDF]

Nat Commun
Wei T, Lan Z, Arikawa Y, Gu Y, Hayakawa T, Morace A, Yamada R, Yamanoi K, Honda K, Kando M, Nakanii N, Mirfayzi SR, Bulanov SV, Yogo A.   +13 more
europepmc   +1 more source

Accelerated increase in plant species richness on mountain summits is linked to warming

Nature, 2018
M. Steinbauer, John‐Arvid Grytnes, G. Jurasinski, A. Kulonen, J. Lenoir, H. Pauli, C. Rixen, M. Winkler, Manfred Bardy-Durchhalter, E. Barni, Anne D. Bjorkman, F. Breiner, S. Burg, P. Czortek, M. A. Dawes, A. Delimat, S. Dullinger, B. Erschbamer, V. A. Felde, Olatz Fernández-Arberas, Kjetil. F. Fossheim, D. Gómez‐García, D. Georges, Erlend T. Grindrud, S. Haider, S. Haugum, Hanne Henriksen, M. Herreros, B. Jaroszewicz, F. Jaroszynska, R. Kanka, J. Kapfer, K. Klanderud, I. Kühn, A. Lamprecht, Magalì Matteodo, U. Cella, S. Normand, A. Odland, S. Olsen, S. Palacio, Martina Petey, Veronika Piscová, Blažena Sedláková, K. Steinbauer, V. Stöckli, Jens‐Christian Svenning, Guido Teppa, J. Theurillat, P. Vittoz, S. Woodin, N. Zimmermann, S. Wipf   +52 more
semanticscholar   +1 more source

Accelerated aging [PDF]

Journal of Experimental Medicine, 2010
openaire   +2 more sources

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

Acceleration of Phase-Modulated Ultrashort Echo Time Sequence for Fast T₂ and Adiabatic T_1ρ Mapping of the Knee Joints. [PDF]

Magn Reson Med
Athertya JS, Moazamian D, Shojaeiadib N, Wang J, Shen X, Jerban S, Du J, Ma Y.   +7 more
europepmc   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Personalized-Context-Aware Age Gap: A New Multi-Omics Measurement Based on Age-Enhanced Model AOE-Net for Aging Acceleration and Chronic Disease Risk Prediction. [PDF]

Aging Cell
Wang FA, Zeng T, Yuan C, Wang H, Yu Y, Deng E, Wang Y, Ji J, Cui J, Tang D, He R, Wang Y, Li Y.   +12 more
europepmc   +1 more source