Results 41 to 50 of about 172,693 (257)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Model Averaging for Accelerated Failure Time Models with Missing Censoring Indicators
MathematicsModel averaging has become a crucial statistical methodology, especially in situations where numerous models vie to elucidate a phenomenon. Over the past two decades, there has been substantial advancement in the theory of model averaging. However, a gap
Longbiao Liao, Jinghao Liu
doaj +1 more source
Fast accelerated failure time modeling for case-cohort data [PDF]
Statistics and Computing, 2013 submitted
Sy Han Chiou +2 more
openaire +3 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A Generalized Accelerated Failure Time Model to Predict Restoration Time from Power Outages
International Journal of Disaster Risk ScienceMajor disasters such as wildfire, tornado, hurricane, tropical storm, and flooding cause disruptions in infrastructure systems such as power and water supply, wastewater management, telecommunication, and transportation facilities.
Tasnuba Binte Jamal, Samiul Hasan
doaj +1 more source
The obesity epidemic in children: Latino children are disproportionately affected at younger ages
International Journal of Pediatrics & Adolescent Medicine, 2015 Background and objectives: National surveillance clearly illustrates that U.S. chil-dren are becoming increasingly overweight. However, the timing of the onset of childhood overweight has not been well-described.
Gilbert C. Liu +4 more
doaj +1 more source
Nonparametric identification of accelerated failure time competing risks models [PDF]
Econometric Theory, 2010 We provide new conditions for identification of accelerated failure time competing risks models. These include Roy models and some auction models. In our setup, unknown regression functions and the joint survivor function of latent disturbance terms are all nonparametric.
Sokbae Lee, Arthur Lewbel
openaire +4 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
BarekengRecidivists, or ex-prisoners who commit crimes after serving a prior sentence, pose a critical challenge to the criminal justice system. This study examines social and economic factors that may reduce the likelihood of recidivists being re-arrested ...
Nuraziza Arfan +3 more
doaj +1 more source