Results 181 to 190 of about 221,595 (265)

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Ubiquitous Expression of <i>mPolg^mut</i> Leads to the Accumulation of Cytotoxic CD8+ T Lymphocytes in Young Mice. [PDF]

Life (Basel)
Kuznetsova NA, Kochegarova KK, Baikova IP, Korshunov EN, Ilchuk LA, Kubekina MV, Bruter AV, Silaeva YY, Varlamova EA.   +8 more
europepmc   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Failure mode and effects analysis nursing model improves recovery and quality of life post-laparoscopic extended radical colectomy for colorectal cancer. [PDF]

World J Gastrointest Surg
Yang QQ, Wu ZK.
europepmc   +1 more source

Multiscale Structuring of Hydroxyapatite via Two‐Photon Lithography of Nanocomposites

Advanced Functional Materials, EarlyView.
Hydroxyapatite scaffolds are of great interest in bone tissue engineering applications, ranging from 3D cell culture to regenerative medicine. Using two‐photon lithography of a transparent nanocomposite, hydroxyapatite microstructures with features ranging from submicron to centimeter‐scale are fabricated. This allows to mimic the natural bone geometry,
Leonhard Hambitzer, Jan Mathis Hornbostel, Richard Prediger, Sebastian Kluck, Michael Daub, Cornelia Lee‐Thedieck, Frederik Kotz‐Helmer   +6 more
wiley   +1 more source

Fanconi anaemia as a human model of accelerated epigenetic and immune ageing.

Ageing Res Rev
Velleuer E, Carlberg C.
europepmc   +1 more source

Associations Between Dietary Habits and Accelerated Aging and the Establishment of an Accelerated Aging Interpretable Risk Prediction Model via Shapley Additive Explanations: Cross-Sectional Study From Two Representative Populations. [PDF]

JMIR Aging
Wu Z, Zhang N, Wang H, Yang Y, Shen H, Zhang Q, Cao Y, Du Y, Ji D.   +8 more
europepmc   +1 more source

Three‐dimensional Antimony Sulfide Based Flat Optics

Advanced Functional Materials, EarlyView.
This work presents the development of a grayscale electron beam lithography (g‐EBL) method for fabricating antimony trisulfide (Sb2S3) nanostructures with customizable 3D profiles. The refractive index of g‐EBL patterned Sb2S3 is determined based on the synergy of genetic algorithm and transfer matrix method.
Wei Wang, Uwe Hübner, Anne Gärtner, Tao Chen, Joseph Köbel, Franka Jahn, Daniel Repp, Abhrodeep Dey, Henrik Schneidwind, Andrea Dellith, Jan Dellith, Torsten Wieduwilt, Matthias Zeisberger, Tanveer Ahmed Shaik, Astrid Bingel, Markus A. Schmidt, Jer‐Shing Huang, Ulf Peschel, Volker Deckert   +18 more
wiley   +1 more source

A prospective cohort study of ultra-rush subcutaneous immunotherapy in dust mite-induced allergic rhinitis. [PDF]

World Allergy Organ J
Xiong Y, Luo W, Peng H, Shen L, Huang Z, Yu J, Ye J.   +6 more
europepmc   +1 more source