Results 81 to 90 of about 6,530 (239)

Accelerated Partial Breast Irradiation for Breast Cancer: A Meta-Analysis

Translational Oncology, 2013
To evaluate the long-term effect of breast conservation with accelerated partial breast irradiation (APBI) for early-stage breast cancer, PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database, Chinese Scientific Journals Full-text Database, and China Journal Full-text Database were searched to identify relevant ...
Ye, Xiu-peng, Bao, Shen, Guo, Li-yun, Wang, Xiao-hu, Ma, Yan-ping, Wei, Zhang, Chun-hua, Wang, Yan-fang, Zhang, Zhi, Feng, Gao, Ying, Tian, Jin-hui, Li, Rong, Gao, Huan-min   +12 more
openaire   +2 more sources

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

Advanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee, Jaeyoung Yoo, Young A. Kim, Zhuodu Wei, Yunseo Lee, Woo‐Jeong Shon, Je Kyung Seong, Seunghee Lee   +7 more
wiley   +1 more source

Retrospective Analysis of the Clinical Usefulness of a Strut-Adjusted Volume Implant in a Single Center

European Journal of Breast Health
Objective: Reports demonstrating the effectiveness and safety of strut-adjusted volume implants (SAVI) in Japan are limited. Therefore, this study aimed to compare the treatment outcomes of SAVI and whole-breast irradiation (WBI) at a single facility ...
Arisa Ata-Shiroshita, Takashi Kuwayama, Masako Kato, Hidenori Shinjo, Kazunori Miyaura, Aya Nagata, Nana Komatsu, Misaki Matsuyanagi, Haruna Sakai, Yuki Matsunaga, Sayuka Nakayama, Ayuha Yoshizawa, Murasaki Ikeda, Kanae Taruno, Hiroko Masuda, Terumasa Sawada, Naoki Hayashi, Yoshinori Ito, Chie Watanabe, Sadako Akashi-Tanaka, Seigo Nakamura   +20 more
doaj   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity

Radiation Oncology, 2010
Background To investigate the efficacy and safety of accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) multicatheter interstitial brachytherapy for early-stage breast cancer.
Kim Ji-Young, Kwak Geum-Hee, Kim Juree, Yeo Seung-Gu, Park Kyeongmee, Kim Eun Seok, Han Sehwan   +6 more
doaj   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

Advanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser, Haseeb Muhammad, Junaid Younas, Gillian Lovell, Bianca Migliori, Andreas Dengel, Sheraz Ahmed   +6 more
wiley   +1 more source

Efficacy and cosmetic outcomes of radiotherapy modalities in early-stage breast cancer: a systematic review and network meta-analysis

Frontiers in Oncology
Breast cancer (BC) is a common malignancy with increasing annual incidence. Radiotherapy shows favorable clinical efficacy in BC management, but limited randomized controlled trial data is a major limitation.
Yushan Dong, Tingting Liu, Peng Wang, Songjiang Liu   +3 more
doaj   +1 more source

Dosimetry evaluation of SAVI-based HDR brachytherapy for partial breast irradiation

Journal of Medical Physics, 2010
Accelerated partial breast irradiation (APBI) with high dose rate (HDR) brachytherapy offers an excellent compact course of radiation due to its limited number of fractions for early-stage carcinoma of breast.
Manoharan Sivasubramanian, Rodriguez R, Bobba Vidya, Chandrashekar Mukka   +3 more
doaj  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source