Results 91 to 100 of about 1,225,869 (253)

Experimental research of electronic products degradation

Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019
With the help of accelerated tests we have obtained experimental data about the degradation of the functional parameters of three types of high-power transistors as the representatives of electronic products.
S. M. Borovikov, E. N. Shneiderov, V. I. Plebanovich, A. I. Berasnevich, I. A. Burak   +4 more
doaj  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Research on Load Torque of Robot Reducer Acceleration Fatigue Tests Based on Adams

Jixie chuandong, 2023
Accuracy and fatigue life are important factors restricting the development of domestic robot reducers. In order to improve the efficiency of fatigue life test, it is very important to select appropriate load torque for accelerated life test.
Chen Lei, Tong Guiying, Mu Yinyin, Qiao Guipeng   +3 more
doaj  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Design and Implementation of Trial Test for Accelerated Life Test

机车电传动, 2019
In order to predict the remaining life of electronic products of rail transit, trial test of ccelerated life test (ALT) was designed and implemented for designing scheme of ALT effectively.
Yuxiong PAN, Guifa ZHOU, Xu WANG
doaj  

ADEQUACY OF THE ACCELERATED AGING TEST FOR SOYBEAN SEEDS

Colloquium Agrariae, 2021
As empresas de sementes utilizam testes de vigor em seus procedimentos internos de controle de qualidade das sementes. Por isso, é necessário escolher métodos eficazes para obter respostas rápidas para a tomada de decisões relacionadas ao manuseio ...
Ana dos Santos Suñe, Andréia da Silva Almeida, Josiane Cantuária Figueiredo, Bruna Barreto dos Reis , Camila de Avila Nunes , Carem Rosane Coutinho Saraiva , Lais Kroessin , William Lorenski Correa, Lilian Vanussa Madruga de Tunes   +8 more
doaj  

Ultraviolet radiation effects [PDF]

Solar ultraviolet testing was not developed which will provide highly accelerated (20 to 50X) exposures that correlate to flight test data. Additional studies are required to develop an exposure methodology which will assure that accelerated testing can ...
Slemp, Wayne S.
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source