Results 61 to 70 of about 1,225,869 (253)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Accelerated Life Test for Reliability Evaluation of Pneumatic Cylinders

IEEE Access, 2018
Pneumatic cylinders are intended to be designed for high reliability and long lifetimes. Evaluating such designs through conventional life tests is difficult as the affordable test time is too short to generate a meaningful amount of failure data.
Juan Chen, Enrico Zio, Jia Li, Zhiguo Zeng, Chong Bu   +4 more
doaj   +1 more source

Accelerated test design [PDF]

The design of an accelerated life test program for electric batteries is discussed. A number of observations and suggestions on the procedures and objectives for conducting an accelerated life test program are presented.
Mcdermott, P. P.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Semi-quantitative temperature accelerated life test (ALT) for the reliability qualification of concentrator solar cells and cell on carriers [PDF]

, 2015
An adequate qualification of concentrator photovoltaic solar cells and cell-on-carriers is essential to increase their industrial development. The lack of qualification tests for measuring their reliability together with the fact that conventional ...
Bosco, Bosco, Crowe, Espinet, Espinet-González, Fthenakis, Fukuda, Garcia, Gold, González, Green, Hayes, Kececioglu, McConnell, Nelson, Núñez, Suhir, Vázquez   +17 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Accelerated Life Test for Photovoltaic Cells Using Concentrated Light

International Journal of Photoenergy, 2016
This paper presents a new method developed to significantly reduce the necessary time for the ageing tests for different types of photovoltaic cells.
Daniel Tudor Cotfas, Petru Adrian Cotfas, Dan Ion Floroian, Laura Floroian   +3 more
doaj   +1 more source

The Alcoa ram fastener: A reusable blind rivet [PDF]

, 1972
Results of tensile, shear, fatigue and accelerated weathering tests are presented for the ram fastener, a reusable, single unit blind rivet. The effects of variations in hole size, grip length and sheet thickness on strength properties of the fastener ...
Dewalt, W. J.
core   +1 more source

Shock acceleration of electrons in the presence of synchrotron losses: I. test particle theory

, 2009
We discuss a semi-analytical solution of the transport equation for electrons at a non-relativistic shock in the presence of synchrotron energy losses. We calculate the spectrum of accelerated (test) particles at any point upstream and downstream of the ...
Ballet, Bamba, Bamba, Bell, Bell, Blasi, Drury, Drury, Kardashev, Lazendic, Lazendic, Pasquale Blasi, Protheroe, Vannoni, Vink, Webb, Webb, Zirakashvili   +17 more
core   +1 more source