Results 101 to 110 of about 649,011 (340)

Accelerating MCMC algorithms [PDF]

WIREs Computational Statistics, 2018
Markov chain Monte Carlo algorithms are used to simulate from complex statistical distributions by way of a local exploration of these distributions. This local feature avoids heavy requests on understanding the nature of the target, but it also potentially induces a lengthy exploration of this target, with a requirement on the number of simulations ...
Robert, Christian P., Elvira, Víctor, Tawn, Nick, Wu, Changye   +3 more
openaire   +5 more sources

Pulsed plasma accelerator operates repetitively without complex controls [PDF]

, 1965
Self-repeating pulsed plasma accelerator operates with a wide variety of gases over a large range of pressures without complex control equipment. The accelerator combines a circular channel with a tangential channel at the entrance way of a high-velocity
Sabol, A. P.
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Evaluating Ascon Hardware on 7-Series FPGA Devices

IEEE Access
The applications regarding the Internet of Things (IoT) demand lightweight and robust cryptographic solutions to ensure authenticated encryption with associated data (AEAD). Also, the lightweight cryptographic solutions that provide data confidentiality,
Adel R. Alharbi, Amer Aljaedi, Abdullah Aljuhni, Moahd K. Alghuson, Hussain Aldawood, Sajjad Shaukat Jamal   +5 more
doaj   +1 more source

Exact Discretization of an Economic Accelerator and Multiplier with Memory

Fractal and Fractional, 2017
Fractional differential equations of macroeconomics, which allow us to take into account power-law memory effects, are considered. We describe an economic accelerator and multiplier with fading memory in the framework of discrete-time and continuous-time
Valentina V. Tarasova, Vasily E. Tarasov
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

AWB-GCN: A Graph Convolutional Network Accelerator with Runtime Workload Rebalancing

Micro, 2019
Deep learning systems have been successfully applied to Euclidean data such as images, video, and audio. In many applications, however, information and their relationships are better expressed with graphs. Graph Convolutional Networks (GCNs) appear to be
Tong Geng, Ang Li, Runbin Shi, Chunshu Wu, Tianqi Wang, Yanfei Li, Pouya Haghi, Antonino Tumeo, Shuai Che, S. Reinhardt, M. Herbordt   +10 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Applying a Living Lab Approach Within an eHealth Accelerator

Technology Innovation Management Review, 2019
Through this study, we seek to understand the impact of the use of the living lab approach on product and business development in an eHealth accelerator.
Lotta Haukipuro, Satu Väinämö, Leena Arhippainen, Timo Ojala   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source