Results 101 to 110 of about 652,834 (343)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Configurable Arithmetic Core Architecture for RNS-CKKS Homomorphic Encryption
IEEE AccessFully Homomorphic Encryption (FHE) provides privacy-preserving applications due to its ability to perform arithmetic computations such as addition and multiplication on encrypted data without decrypting them first.
Chulwoo Lee +3 more
doaj +1 more source
Accelerating MCMC algorithms [PDF]
WIREs Computational Statistics, 2018 Markov chain Monte Carlo algorithms are used to simulate from complex statistical distributions by way of a local exploration of these distributions. This local feature avoids heavy requests on understanding the nature of the target, but it also potentially induces a lengthy exploration of this target, with a requirement on the number of simulations ...
Robert, Christian P. +3 more
openaire +5 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Evaluating Ascon Hardware on 7-Series FPGA Devices
IEEE AccessThe applications regarding the Internet of Things (IoT) demand lightweight and robust cryptographic solutions to ensure authenticated encryption with associated data (AEAD). Also, the lightweight cryptographic solutions that provide data confidentiality,
Adel R. Alharbi +5 more
doaj +1 more source
Exact Discretization of an Economic Accelerator and Multiplier with Memory
Fractal and Fractional, 2017 Fractional differential equations of macroeconomics, which allow us to take into account power-law memory effects, are considered. We describe an economic accelerator and multiplier with fading memory in the framework of discrete-time and continuous-time
Valentina V. Tarasova, Vasily E. Tarasov
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Pulsed plasma accelerator operates repetitively without complex controls [PDF]
, 1965 Self-repeating pulsed plasma accelerator operates with a wide variety of gases over a large range of pressures without complex control equipment. The accelerator combines a circular channel with a tangential channel at the entrance way of a high-velocity
Sabol, A. P.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Applying a Living Lab Approach Within an eHealth Accelerator
Technology Innovation Management Review, 2019 Through this study, we seek to understand the impact of the use of the living lab approach on product and business development in an eHealth accelerator.
Lotta Haukipuro +3 more
doaj +1 more source