Results 21 to 30 of about 5,612 (169)

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3’,5’-bisphosphate as a potent enzyme inhibitor

Communications Biology
XRN1 (5’-3’ exoribonuclease 1) degrades RNA from the 5′ → 3′ direction and utilizes both single- and double-stranded RNA as substrates. XRN1 plays a critical role in mRNA turnover as well as regulating the cellular response to viral infection.
Gordon J. Lockbaum, Maureen M. Lynes, Sophie A. Shen, Julie Liu, Nicholas Holt, Sunaina P. Nayak, Kevin E. Knockenhauer, Shihua Yao, E. Allen Sickmier, Anugraha Raman, Jie Wu, April Case, Livia Shehaj, Shane M. Buker, Simina Grigoriu, Scott Ribich, Stephen J. Blakemore, Brian A. Sparling, Kenneth W. Duncan, Robert A. Copeland, Serena J. Silver, P. Ann Boriack-Sjodin   +21 more
doaj   +1 more source

The KIF18A Inhibitor ATX020 Induces Mitotic Arrest and DNA Damage in Chromosomally Instable High-Grade Serous Ovarian Cancer Cells

Cells
High-grade serous ovarian cancer (HGSOC) is the most common (~80%) and lethal ovarian cancer subtype in the United States, characterized by TP53 mutations and DNA repair defects causing chromosomal instability (CIN).
Jayakumar Nair, Tzu-Ting Huang, Maureen Lynes, Sanjoy Khan, Serena Silver, Jung-Min Lee   +5 more
doaj   +1 more source

On the Question of the Cheboksary Shibboleth

Этническая культура, 2022
The work is devoted to the study of the shibboleth in the speech culture of the inhabitants of the capital of Chuvashia. A shibboleth is a word that has absorbed the specific features of a language and is used to identify people for whom this language is
Eduard V. Fomin
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

IGNATS KUNOSH’S GIFTS TO ANATOLIAN FOLKLORE AND LINGUISTICS

Uluslararası Türk Lehçe Araştırmaları Dergisi, 2018
Ignats Kunosh is a Hungarian turkologist with the origin Jew devoted his life to the collecting of Turkic folk literature and studying the forgetton accents and dialects.
Gumru ŞEHRİYAR
doaj   +1 more source

On the prosodic traits of the declension of nouns in the Ijekavian West-Serbian speeches [PDF]

Južnoslovenski Filolog, 2019
The paper systematically and analytically delves into conspicuous accent characteristics of the declension of nouns in the Ijekavian West-Serbian speeches (less commonly of lexical categories and individual examples). The demonstrated instances (
Marković Slavoljub Z.
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Accent Imitation Positively Affects Language Attitudes

Frontiers in Psychology, 2013
People in conversation tend to accommodate the way they speak. It has been assumed that this tendency to imitate each other’s speech patterns serves to increase liking between partners in a conversation.
Patti eAdank, Patti eAdank, Andrew J. Stewart, Louise eConnell, Jeffrey eWood   +4 more
doaj   +1 more source