Results 71 to 80 of about 16,288 (235)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Post-focal and factive deaccentuation in Persian
Glossa, 2018 Two experiments were carried out to examine whether the Persian word accent is deleted in two putative deaccenting contexts, post-focal regions and presupposed embedded clauses, to the extent that accentual minimal pairs become homophonous.
Carlos Gussenhoven +2 more
doaj +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
L’accent français en Allemagne, l’accent allemand en France - apparition, perception et disparition d'un signe identitaire distinctif [PDF]
Synergies Pays Germanophones, 2019 L’accent est la prononciation spécifique d’un étranger qui parle une autre langue que sa langue maternelle. Même s’il s’installe dans son pays d’accueil et s’il ressemble physiquement à la majorité de ses habitants, son accent le trahira : ouvrir la ...
Dana Martin
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Accents et insécurité linguistique en cours d’anglais : le cas d’étudiants de LEA
Lidil, 2019 This article explores the process of learning a foreign language from a sociolinguistic point of view. More specifically, it investigates students’ accents and linguistic insecurity, in relation to certain linguistic norms prescribed by the curriculum ...
Sylvie Wharton, Rhian Wolstenholme
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
An analysis and description of case marking in four Persian dialects of Khuzestan [PDF]
مطالعات زبانها و گویشهای غرب ایران, 2015 Case marking is one way of showing grammatical relationships between the constituents in the sentences. In this study, case marking will be discussed in four Persian dialects of Khuzestan, namely Dezfuli, Shushtari, Behbahani and Hendijani.
zahra Hamedi shirvan +2 more
doaj