Results 31 to 40 of about 31,712 (242)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Effectiveness of Acceptance and Commitment Therapy (ACT) on Resilience in Elderlies [PDF]

روانشناسی پیری, 2017
  In recent years, hostile environments and sources of stress have been increasing. On the other hand, the elderly population in the world is on the rise.
Javad Seyyedjafari, Abdolah Motamedi, Mohammad Mehradsadr, Marziye Olamaie Kopaei, Sepehr Hashemian   +4 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The effectiveness of acceptance- and commitment-based therapy on perception of disease in patients with irritable bowel syndrome

International Archives of Health Sciences, 2020
Aims: The purpose of this study was to investigate the effectiveness of acceptance and commitment therapy on perception of disease in patients with irritable bowel syndrome (IBS).
Sedighe Aghalar, Fardin Moradi Manesh, Naser Saraj Khorami, Fariba Hafezi   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Comparison of the efficacy of acceptance and commitment-based therapy and schema therapy on self-efficacy and craving for change in addicts

مجله علوم روانشناختی, 2021
Background: Studies have shown that low self-efficacy and poor beliefs in abilities in stressful situations are two causes of substance abuse and relapse of addictive behaviors.
Fatemeh Bahram Abadian, Mina Mojtabaie, Mehrdad Sabet   +2 more
doaj  

Effect of Acceptance and Commitment Therapy on Impulsivity of Patients With Methamphetamine Use Disorder

Journal of Rehabilitation, 2020
Objective: Executive functions and impulse control ability are severely impaired in people with amphetamine use disorders. In this regard the study aims to decrease impulsivity in patients with Methamphetamine use disorder by using Acceptance and ...
Mahdi Yousefi, Seyyed Jalal Younesi, Ali Farhoudian, Mohammad Hadi Safi   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source