Results 201 to 210 of about 170,171 (257)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

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Acceptance and Commitment Therapy (ACT) for Cancer Patients

2021
Acceptance and commitment therapy (ACT) is often described as one of the newer “third wave” cognitive behavioral therapies. ACT is transdiagnostic and functions by increasing psychological flexibility and training skills in appropriate behavioral responses to distressing cognitions and emotions.
Nicholas J. Hulbert-Williams, Ray Owen, Christian J. Nelson   +2 more
openaire   +1 more source

What Is Acceptance and Commitment Therapy (ACT)?

2020
This chapter provides a broad overview of acceptance and commitment therapy (ACT), including empirical evidence for its effectiveness, how it fits with other cognitive-behavioral therapies, and defining features of ACT. The chapter also explains the theory and scientific philosophy underlying ACT so that readers have a framework to which to refer as ...
Michael P. Twohig, Michael E. Levin, Clarissa W. Ong   +2 more
openaire   +1 more source

Acceptance and Commitment Therapy (ACT) for Chronic Pain

The Clinical Journal of Pain, 2017
Objectives: Chronic pain places a burden on individuals and the economy. Although there is evidence for the effectiveness of cognitive-behavior therapy, it is recognized that the effects are limited. Acceptance and Commitment Therapy (ACT), which aims to increase valued action in the presence of pain, has been suggested as an ...
Laura S, Hughes, Jodi, Clark, Janette A, Colclough, Elizabeth, Dale, Dean, McMillan   +4 more
openaire   +2 more sources

Bewegen richting flexibiliteit met Acceptance and Commitment Therapy (ACT)

GZ - Psychologie, 2011
Acceptance and Commitment Therapy (ACT) is een relatief nieuwe therapievorm die gebaseerd is op de gedragsanalyse, met name de Relational Frame Theory (RFT). ACT is onderdeel van de ‘derde generatie cognitieve gedragstherapieen’. Deze nieuwe golf van therapieen gaat uit van het idee dat pijn een basiskenmerk is van het menselijk bestaan. Zo baseert ACT
G. Jansen, D.A. Rinsampessy, G.J. van den Berg, H.R.A. De Mey   +3 more
openaire   +1 more source

Acceptance and Commitment Therapy (ACT): An Overview for Practitioners

Australian Journal of Guidance and Counselling, 2012
Acceptance and Commitment Therapy (ACT) offers school counsellors a practical and meaningful approach to helping students deal with a range of issues. This is achieved through encouraging psychological flexibility through the application of six key principles. This article describes our introduction to ACT, ACT's application to children and adolescents,
Tim Bowden, Sandra Bowden
openaire   +1 more source

[ACCEPTANCE AND COMMITMENT THERAPY (ACT): BEHAVIORISM, MINDFULNESS AND VALUES].

Vertex (Buenos Aires, Argentina), 2016
Over the last decades a series of psychological treatments labeled have been developed. Acceptance and Commitment Therapy (ACT) is a third generation therapy that essentially seeks to promote the acceptance of private events in opposition to their modification or change, with the aim of promoting cognitive flexibility.
Juan P, Coletti, Germán L, Teti
openaire   +2 more sources