Results 41 to 50 of about 6,044,865 (277)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modeling Services Acceptance Factors of Mobile Government (M-Government)

Asia-Pacific Journal of Information Technology and Multimedia, 2012
Advancement in information and communication technologies (ICTs), particularly the rapid changes in mobile technologies have led to development of new applications and services.
Ahmad Althunibat, Nor Azan Mat Zin, Noraidah Sahari @ Ashaari   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Examining the Auditors’ Acceptance of Big Data Analytics Technology Platform: Evidence from Government Auditors in Indonesia

The Indonesian Journal of Accounting Research, 2023
This study examines the determinants of auditors’ acceptance of big data analytics (BDA) technology. Using the responses from 83 government auditors, we test the model built from the Unified Theory of Acceptance and Usage of Technology (UTAUT) theory and
Fauzan Wahyuabdi Pratama, Erna Fitri Komariyah   +1 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reflection on the theory of the Arab origin of the Yoruba people

Theologia Viatorum, 2021
The theory of the Arab origin of the Yoruba people is seemingly the oldest amongst other theories of their origins. This is because the original Yoruba oral tradition pertaining to their origin subscribes to the ‘East’ as the location of their origin ...
Jock M. Agai
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Leadership Communication and Implications For Acceptance of The Go-Biz Application By MSMEs Employees (Case Study: Bogor District)

Jurnal Aplikasi Bisnis dan Manajemen
Background: Leaders of micro, small, and medium enterprises (MSMEs) have a role in the continuity of a business. Purpose: This research aims to examine the influence of leadership communication on the acceptance of the Go-Biz application by MSME ...
Nadia Nur Soraya, Sarwititi Sarwoprasodjo, Irman Hermadi   +2 more
doaj   +1 more source