Results 131 to 140 of about 100,540,696 (301)

"None of us are lying": an interpretive description of the search for legitimacy and the journey to access quality health services by individuals living with Long COVID. [PDF]

BMC Health Serv Res, 2023
Brehon K, Miciak M, Hung P, Chen SP, Perreault K, Hudon A, Wieler M, Hunter S, Hoddinott L, Hall M, Churchill K, Brown DA, Brown CA, Bostick G, Skolnik K, Lam G, Weatherald J, Gross DP.   +17 more
europepmc   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

School-Based Health Services to Improve Youth Access to Reproductive Health Care

Social Sciences
School-based health centers (SBHCs) provide accessible, comprehensive healthcare to students, particularly in underserved communities, and play a critical role in addressing reproductive health needs.
Elissa M. Barr, Ashley Sarra Mezzano, Carmen Smotherman, Kassie R. Terrell, Michele J. Moore   +4 more
doaj   +1 more source

Poor access to health services for depression treatment in Brazil. [PDF]

Rev Saude Publica, 2023
Bezerra HS, Barbosa IR.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

The Connecticut Office of Health Care Access 2004 Small Employer Health Insurance Survey-focus on results /

, 2004
Title from caption.; "Planning tomorrow's health care system today."; "November 2004."; Updates: Employer-sponsored health insurance / Office of Health Care Access. Hartford, CT : Office of Health Care Access, [2001]

core   +1 more source

Combined on- and off-site training contributes to strengthening the unified pharmaceutical system in the Dominican Republic

Journal of Pharmaceutical Policy and Practice, 2014
Edgar Barillas, Claudia Valdez, Paula Diaz, Maria Elena Tapia   +3 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

A refugee mother's perspective: Healthcare satisfaction and access to health services as an immigrant in Turkiye. [PDF]

North Clin Istanb, 2023
Durmaz N, Ulukol B, Bilirer S, Erguder T.   +3 more
europepmc   +1 more source