Results 111 to 120 of about 96,876,350 (295)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

[Access to health services. A geographical approach to public health].

Revista de saude publica, 1987
O acesso da população aos serviços de saúde é um pré-requisito de fundamental importância para uma eficiente assistência à saúde. A localização geográfica dos serviços é um dos fatores que interferem nessa acessibilidade. Pretendeu-se estudar a localização dos serviços de saúde. A proposta básica foi a de apresentação de uma metodologia considerando-se
Unglert, Carmen Vieira de Sousa, Rosenburg, Cornélio Pedroso, Junqueira, Claudette Barriguela   +2 more
openaire   +2 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Inclusion of Persons with Disabilities in the Health Financing System in Tanzania [PDF]

, 2013
This report assesses the potential barriers and obstacles that people with disabilities might face when accessing health care services. It is the overall objective of this study to provide evidence on obstacles and financial barriers that people with ...
Ifakara Health Institute, (IHI)
core  

Report of the Region 5 Pediatric Inpatient Psychiatric Services Implementation Group

, 2007
Title from PDF cover (viewed May 29, 2009).; At head of title: State of Connecticut.; "Prepared for: Cristine A.
Connecticut. Region 5 Pediatric Inpatient Psychiatric Services Implementation Group.
core   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

"None of us are lying": an interpretive description of the search for legitimacy and the journey to access quality health services by individuals living with Long COVID. [PDF]

BMC Health Serv Res, 2023
Brehon K, Miciak M, Hung P, Chen SP, Perreault K, Hudon A, Wieler M, Hunter S, Hoddinott L, Hall M, Churchill K, Brown DA, Brown CA, Bostick G, Skolnik K, Lam G, Weatherald J, Gross DP.   +17 more
europepmc   +2 more sources

Ritshidze’s community-led monitoring system as a source of information on health system responsiveness in South Africa

South African Medical Journal
Ritshidze is a large-scale community-led monitoring (CLM) system in South Africa, which has been conducting quarterly surveys of patient experiences at >400 primary healthcare facilities and community sites since 2019.
P Barron, B Honermann, K Vallabhjee, K Govender, H Schneider   +4 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Department of Health and Community Services : Professional stream recruitment and retention project - final report

, 2002
Department of Health and Community Services : Professional stream recruitment and retention ...
Hancock, C, Strategic Workforce Services
core