Results 81 to 90 of about 1,460,372 (264)

Older Adults’ Access to Pharmacological Treatment, a Human Right to Health: Scoping Review (2020–2025)

Pharmacy
Background: Limitations in timely and equitable access to essential medicines among older adults not only constitute a clinical barrier to the effective management of chronic conditions, but also represent a violation of the fundamental right to life ...
Doris Cardona, Valeria Santacruz-Restrepo, Juliana Madrigal-Cadavid, Alejandra Rendón-Montoya, Angela Segura-Cardona, Jorge Iván Estrada-Acevedo, Marcela Agudelo-Botero   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

POVERTY LEVELS MUST BE REDUCED TO IMPROVE ACCESSIBILITY TO HEALTH SERVICES

Jurnal Administrasi Kesehatan Indonesia
Background: Access to health services is a fundamental right for every citizen, but its equitable distribution remains challenging due to the influence of several variables.
Desri Yesi, Ekowati Retnaningsih, Pardomuan Robinson Sihombing, Nuryanto Nuryanto, Irni Novitha   +4 more
doaj   +1 more source

HEALTH SERVICE REFORMS AND ACCESS TO SPECIALIST SERVICES [PDF]

Rheumatology, 1991
M A, Chamberlain, A, Tennant
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Acesso e equidade nos serviços de saúde: uma revisão estruturada

Saúde em Debate
RESUMO Artigo de revisão de literatura sobre a organização de serviços da Atenção Primária à Saúde em suas dimensões de acesso e equidade. Os artigos foram identificados nas bases de dados da Biblioteca Virtual em Saúde (Centro Latino-Americano e do ...
Fernando Passos Cupertino de Barros, Jéssica de Souza Lopes, Ana Valéria Machado Mendonça, Maria Fátima de Sousa   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Parents’ perspective on children’s access to healthcare services and associated factors: a cross-sectional study

BMC Public Health
Background Poor access to health services endangers children’s health and development. Parents’ perspectives are essential for understanding barriers to children’s healthcare access, as they often serve as primary caregivers and decision-makers.
Nona Salimi, Javad Javan-Noughabi, Vahid Ghavami, Reza Matinfar, Fatemeh Kokabisaghi   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source