Results 61 to 70 of about 1,521,034 (349)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Difficulties and advances in access to and use of health services by transgender women and travestis in Brazil [PDF]

Revista Brasileira de Epidemiologia
Objective: To understand the narratives of transgender women and travestis (TGW) from four Brazilian cities regarding access to and use of health services.
Thiago Félix Pinheiro, Paula Galdino Cardin de Carvalho, Gabriel Nolasco, Lorruan Alves dos Santos, Maria Amélia de Sousa Mascena Veras   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Access Barriers to Services Markets: Mapping, tracing, understanding and measuring. CEPS Special Report No. 77, June 2013 [PDF]

, 2013
EU and national policy-makers argue that the single services market is a key to EU growth, but that many barriers to services market access remain. Grasping the scope, nature and economic meaning of these barriers, however, has proven rather difficult ...
Mustilli, Federica, Pelkman, Jacques
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‘I Didn’t Know Where to Go’: A Mixed-Methods Approach to Explore Migrants’ Perspectives of Access and Use of Health Services during the COVID-19 Pandemic [PDF]

, 2022
The COVID-19 pandemic put pressure on health systems, affecting populations’ use of health services, especially those experiencing increased difficulties in healthcare access, as some migrant groups.
Machado, Ana Sá, Azeredo-Lopes, Sofia, Maria J. Marques, João Victor Rocha, Gama, Ana, Sofia Azeredo-Lopes, Ana Sá Machado, Sónia Dias, Rocha, João Victor, Dias, Sónia, Walaa Kinaan, Kinaan, Walaa, Ana Gama, Marques, Maria J.   +13 more
core   +1 more source

Towards “Zero by 30”, the Kenyan case: a systematic exploration of barriers to rabies policy implementation through systems thinking

Health Research Policy and Systems
Introduction Rabies is a neglected tropical disease (NTD) that disproportionately affects marginalized communities, despite the availability of effective vaccines.
Laurent Smets, Sanjeet Kumar Jaiswar, Valentijn Stienen, Benedict Mueke Muma, Vincent Okungu, Nico Vandaele, Catherine Decouttere   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Assessing capacities and resilience of health services during the COVID-19 pandemic: Lessons learned from use of rapid key informant surveys

Frontiers in Public Health, 2023
This article is part of the Research Topic‘Health Systems Recovery in the Context of COVID-19 and Protracted Conflict.’ProblemMany countries lacked rapid and nimble data systems to track health service capacities to respond to COVID-19. They struggled to
Briana Rivas-Morello, Dirk Horemans, Kavitha Viswanathan, Chelsea Taylor, Andrea Blanchard, Humphrey Karamagi, Benson Droti, Regina Titi-Ofei, Laetitia Ouedraogo Nikiema, Moussa Traore, Hillary Kipruto, Amalia del Riego, Natalia Houghton, Hassan Salah, Deena Alasfoor, Henry Doctor, Ardita Tahirukaj, Florian Tille, Tomas Zapata, Kathryn O'Neill   +19 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Knowledge Summary 20: Access to Family Planning [PDF]

, 2012
Ensuring universal access to reproductive health and rights, including family planning, is key to achieving global goals to improve women’s and children’s health.
Partnership for Maternal, Newborn and Child Health
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