Results 101 to 110 of about 185,486 (298)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Action Committee Meeting of Provincial and Territorial Access to Justice Groups

open access: yes, 2015
On March 13, 2015 the Action Committee on Access to Justice in Civil and Family Matters (the Action Committee) convened a meeting for existing provincial and territorial access to justice groups (P/T A2J groups), many of which were formed in response to ...
Action Committee on Access to Justice in Civil and Family Matters
core  

Access to justice for people with disabilities as victims of crime in Ireland [PDF]

open access: yes, 2018
International literature recognises that people with disabilities are at greater risk of crime than their able-bodied counterparts, but that crime against people with disabilities is significantly under-reported and often fails to proceed to prosecution.
Edwards, Claire   +2 more
core  

Providing an Architecture Framework for Cyberjustice

open access: yesLaws, 2014
The paper illustrates how architecture can be used to show the contribution and the use of technology in the legal system. The models created enable the rapid identification of the stakeholders, their objectives, the technologies they use, and their ...
Benoit A. Aubert   +2 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

ACESSO À JUSTIÇA E CUSTAS JUDICIAIS: UMA DICOTOMIA

open access: yesColloquium Humanarum, 2010
The study examines the dichotomy between the constitutional guarantee of access to judicial and expenses required by the state judge to conduct the exercise of judicial activity.
Caricielli Maisa Longo   +1 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

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