Results 51 to 60 of about 1,856,725 (298)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A Perspective from the Judiciary on Access to Justice [PDF]
, 2019 I decided early in 2009, upon becoming Chief Judge and the steward of the justice system in New York, to focus my energy on ensuring that everyone gets their day in court.
Lippman, Jonathan
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Mediation, Self-Represented Parties, and Access to Justice: Getting There from Here [PDF]
, 2019 Mediation is enthusiastically promoted as a vehicle for providing access to justice. This is as true in developing countries as it is in the United States.
Nolan-Haley, Jacqueline
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
ACCESS TO JUSTICE AND ABUSES OF CONTRACT
The Windsor Yearbook of Access to Justice, 2017 Mass-market standardized fine print (boilerplate) altering the rights of consumers is greatly expanding in today’s digital environment Mass-market boilerplate impacts access to justice when it deletes rights to redress of grievances.
Margaret Jane Radin
doaj +1 more source
, 2018 On October 27, 2017, the Stein Center for Law and Ethics in conjunction with the Fordham Law Review hosted a Colloquium entitled Access to Justice and the Legal Profession in an Era of Contracting Civil Liability.
Zipursky, Benjamin C.
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
FREE ACCESS TO JUSTICE AND PROCEDURAL LIABILITY
Revista Eletrônica de Direito Processual, 2018 The essay proposes a rational analysis of the procedural law wich grants free access to the legal system to those who can‟t afford it, proposing that the effects of the decision wich grants this benefit should be restricted in order to guarantee wide ...
Lucas Pahl Schaan Núñez
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source