Results 101 to 110 of about 555,884 (236)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Rarely listed essential medicines in 158 national lists

Journal of Pharmaceutical Policy and Practice
Background Health needs are relatively similar across the planet as there are few conditions that are truly unique to one region or country, and most conditions are common around the world.
Moizza Zia Ul Haq, Camila Heredia, Amal Rizvi, Aine Workentin, Nav Persaud   +4 more
doaj   +1 more source

The drugs don’t work: access to medicines in the developing world [PDF]

, 2005
No description ...
Guadamuz González, Andrés
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The Potential of Incorporating a Pharmacist-Only Medicine Category in Poland

Scientia Pharmaceutica
Pharmacists play an important role, being increasingly focused on patient care and pharmaceutical services. This trend is also noticeable in Poland. Thus, we aimed to study the opinions of Polish pharmacists to determine the potential for introducing a ...
Tomasz Zaprutko, Józefina Sprawka, Barbara Maciuszek-Bartkowska, Piotr Ratajczak, Dorota Kopciuch, Anna Paczkowska, Krzysztof Kus   +6 more
doaj   +1 more source

Framing access to medicines in developing countries: an analysis of media coverage of Canada's Access to Medicines Regime

BMC International Health and Human Rights, 2010
Background In September 2003, the Canadian government committed to developing legislation that would facilitate greater access to affordable medicines for developing countries.
Cosio Andrea, Kuek Victoria, Phillips Kaye, Esmail Laura C, Kohler Jillian   +4 more
doaj   +1 more source

25 years of the WHO essential medicines lists: progress and challenges. [PDF]

, 2003
The first WHO essential drugs list, published in 1977, was described as a peaceful revolution in international public health. The list helped to establish the principle that some medicines were more useful than others and that essential medicines were ...
't Hoen, 't Hoen, Andy Gray, Brenda Waning, Chetley, Editorial, Ellen 't Hoen, Executive Board, Gray, Gray, Gray, Hogerzeil, Howard, Kanji, Maritoux, Nathan Ford, Quick, Quick, Richard Laing, Scholtz, Steiger, Trouiller, Velasquez   +22 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Digital Transformation in the Health Product Supply Chain: A Framework for Analysis

Health Systems & Reform
Well-functioning supply chains for medicines and other health products are vital for a health system’s goals of ensuring access, quality, and efficiency.
Prashant Yadav
doaj   +1 more source