Results 161 to 170 of about 1,872,650 (338)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Digital accessibility: Challenges and opportunities

open access: yesIIMB Management Review, 2019
This round table is focussed on outlining barriers to digital accessibility, solutions, and possible next steps to ensuring digital accessibility.
Mukta Kulkarni
doaj  

Psychosocial Complaints and Life Satisfaction Among Greek University Students: A Pre- and Pandemic-Era Comparison

open access: yesCOVID
This study aims to identify and compare the prevalence and risk factors associated with psychosocial and psychological complaints, as well as life and study satisfaction, among Greek undergraduate students before and during the COVID-19 pandemic.
Magdalini Katsikidou   +7 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Discursive work within weak field mandate events: The case of a conference on assistive technologies for persons with disabilities

open access: yesIIMB Management Review, 2018
The present study outlines discursive work in a weak field mandate event. The case is a conference focussed on assistive technologies that may help persons with disabilities gain better access to educational and employment spaces in India.
Mukta Kulkarni
doaj  

Water Accessibility of Poly vinylalcohol Fibre

open access: bronze, 1957
Naomichi Takahashi   +2 more
openalex   +2 more sources

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