Results 201 to 210 of about 1,872,650 (338)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Analyzing Disparity in Geographical Accessibility to Home Medical Care Using a Claims Database and Geographical Information System: Simulation Study. [PDF]

JMIR Aging
Morii Y, Nakanishi Y, Nishioka Y, Tsugihashi Y, Noda T, Myojin T, Imamura T, Akahane M.   +7 more
europepmc   +1 more source

Ability of an Incompatible Race of Erysiphe graminis hordei to Induce an Accessibility to the Same Race in Heat-Predisposed Barley Leaves

, 1977
Seiji OUCHI, Hideto NAKABAYASHI, Hachiro Oku   +2 more
openalex   +2 more sources

Accessibility of Ion-Ion Hybrid Resonance [PDF]

, 1973
Hantao Ji, K. Matsuura
openalex   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Optimizing accessibility utilizing simulation-based framework for efficient resource allocation and scheduling for disability-friendly utilities. [PDF]

Sci Rep
Alqahtani FK, Sherif M, Ghanem A, Abdelhafeez M, Shafaay MA.   +4 more
europepmc   +1 more source

Some Problems with Accessibility Standards: A Comparison of Household Preferences to Standards for Work, Shopping, and School Trips [PDF]

, 1973
Edward J. Kaiser, Edgar W. Bulter, Ronald J. McAllister, Russell W. Thibeault   +3 more
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response. [PDF]

Mol Metab
de Smalen LM, Adak V, Leuchtmann AB, Schneider-Heieck K, Steurer SA, Handschin C.   +5 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source