Results 241 to 250 of about 1,872,650 (338)

Equity, Efficiency, and Accessibility in Urban and Regional Health-Care Systems [PDF]

, 1982
L. Mayhew, Giovanni Leonardi
openalex   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

STEMIN transcription factor drives selective chromatin remodeling for gene activation within a relaxed chromatin during reprogramming in the moss Physcomitrium patens. [PDF]

Plant J
de Villiers RM, Palfalvi G, Kanai A, Suzuki Y, Hasebe M, Ishikawa M.   +5 more
europepmc   +1 more source

The accessibility of DNA to dimethylsulfate in complexes with recA protein. [PDF]

, 1987
E. Di Capua, Berndt Müller
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Identifying key complex relations between education and healthcare in the Netherlands for future pandemic management. [PDF]

Health Res Policy Syst
Hadjisotiriou S, Coenen J, Rouwette EAJA, Nespeca V, Oreel TH, Marchau VAWJ, Vasconcelos VV, Quax R, Wertheim HFL, Olde Rikkert MGM, Korzilius HPLM.   +10 more
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Correction: It's not all abundance: Detectability and accessibility of food also explain breeding investment in long-lived marine animals. [PDF]

PLoS One
PLOS One Staff.
europepmc   +1 more source

Public space without architectural barriers as friendly and accessible for people with disabilities

, 1970
Kamil Rawski
openalex   +2 more sources

The Accessibility of the Active Site and Conformation States of the β₂ Subunit of Tryptophan Synthase Studied by Fluorescence Quenching [PDF]

, 1983
Andrew N. Lane
openalex   +1 more source