Results 191 to 200 of about 708,845 (350)

Ten simple rules for making biomedical data resources accessible. [PDF]

PLoS Comput Biol
Smits TC, Weru L, Gehlenborg N, L'Yi S.
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Challenges and Practices in Perishable Food Supply Chain Management in Remote Indigenous Communities: A Scoping Review and Conceptual Framework for Enhancing Food Access. [PDF]

Int J Environ Res Public Health
Gharakhani Dehsorkhi B, Afif K, Doyon M.
europepmc   +1 more source

You Are What You Read: Gender-Typed Lifestyle Magazine Exposure In Relation To Gender Conformity and Attitude Accessibility

, 2009
Stephanie Soduk
openalex   +1 more source

Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding [PDF]

, 1995
Jeffrey K. Myers, C. Nick Pace, J. Martin Scholtz   +2 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The E-bike: opportunities for commuter traffic. The potentials of using electric bicycles and –scooters in commuting traffic in relation to energy use, local emissions and the accessibility of a compact Dutch city

, 2012
Wiebe Engelmoer
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Applying a Novel Measure of Community-Level Healthcare Access to Assess Breast Cancer Care Timeliness. [PDF]

Cancer Epidemiol Biomarkers Prev
Dunn MR, Niu H, Li D, Emerson MA, Thompson CA, Nichols HB, Roberson ML, Wheeler SB, Hyslop T, Elston Lafata J, Troester MA.   +10 more
europepmc   +1 more source

Exploring Accessibility Scenarios for 2020 in Relation with Future ICT Trends on Assistive Technology and Accessibility

, 2012
Christos Kouroupetroglou, Dimitris Tektonidis, Adamantios Koumpis, Ioannis Ignatiadis   +3 more
openalex   +2 more sources