Results 261 to 270 of about 4,064,536 (382)

Commentary: Trustworthy and ethical AI in digital mental healthcare - wishful thinking or tangible goal? [PDF]

Internet Interv
Svensson E, Osika W, Carlbring P.
europepmc   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Engaging Stakeholders in the Development of a National Digital Mental Health Strategy: Reflexive Thematic Analysis.

J Med Internet Res
Kennedy S, Fitzgerald R, Melia R.
europepmc   +1 more source

Impact on Health, Resources, and Satisfaction: A Qualitative Study of Primary Health Care Case-Management Nurses. [PDF]

Healthcare (Basel)
Molina-Gil MJ, Guerra-Martín MD, Diego-Cordero R.   +2 more
europepmc   +1 more source

Quality and Accessibility of Food-Related Data [PDF]

The American Journal of Clinical Nutrition, 1996
openaire   +2 more sources

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Spatial organization, chromatin accessibility and gene-regulatory programs defining mouse sensory neurons. [PDF]

Commun Biol
Krauter D, Kupari J, Usoskin D, Su J, Hu Y, Zhang MD, Ernfors P.   +6 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

'Removing a Blindfold': Perspectives of Physical Therapists After Completing the PEAK-Portuguese E-Learning Course. [PDF]

Musculoskeletal Care
Almeida Silva HJ, Saragiotto BT, Fernandes LG, Perea JPM, Ferrari AV, Locatelli IP, Hinman RS, Salvini TF.   +7 more
europepmc   +1 more source