Results 91 to 100 of about 7,868,926 (302)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Linked data for accessibility: from techniques to users
, 2013 The advanced characteristics of Linked Data drive the dramatic growth of accessible public data. With very few accessibility research projects applying Linked Data , this paper reviews the challenges of accessibility and proposes the approach to use ...
Ding, Chaohai, Wald, Mike, Wills, Gary
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Accessible Environment for Young People with Disabilities in St Petersburg: Sociological Analysis
ДискурсIntroduction. The article is devoted to the opportunities and barriers of the environment. It is proposed to look at the creation of an “accessible environment” not only as the elimination of physical barriers, but also from the point of view of its ...
O. A. Novozhilova
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
ACCESSIBLE BUILT ENVIRONMENT FOR THE ELDERLY AND DISABLED IN MALAYSIA: HOTELS AS CASE STUDIES [PDF]
Journal of Construction in Developing Countries, 2010 In Malaysia, it has become of increasing importance to study ways to improve the level of accessibility in buildings for the elderly and disabled people in the built environment, especially in hotels and resorts.
Asiah Abdul Rahim, Nur Amirah Abd. Samad
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Accessible Mathematics: Representation of Functions through Sound and Touch
, 2023 reservedThis thesis has as its primary objective the providing of a new tool which allows people visually impaired to learn math functions by the extensive use of sounds and touch.
GATTO, SALVATORE
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source