Results 181 to 190 of about 1,355,131 (295)

Open access [PDF]

Nature Materials, 2012
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Corrigendum: <i>Corynebacterium drakensteinense</i> sp. nov., isolated from the nasopharynx of a healthy South African infant. [PDF]

Int J Syst Evol Microbiol
Haines RR, Basuki A, Tenaglia VP, Zar HJ, Nicol MP, Bahal RK.   +5 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ITS2 and 18S rRNA gene sequence-structure phylogeny of the Haptophyta (Haptista). [PDF]

PLoS One
Ridder L, Edvardsen B, Wolf M.
europepmc   +1 more source

Random Access [PDF]

British Journal of General Practice, 2017
openaire   +2 more sources

Beyond Access into Accessibility [PDF]

Science Editor, 2021
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Proposal of <i>Allobrachymonas</i> gen. nov. and three new combinations as replacement names for the illegitimate prokaryotic genus name <i>Brachymonas</i>, proposal of <i>Allobosea</i> gen. nov. and 12 new combinations as replacement names for the illegitimate prokaryotic genus name <i>Bosea</i> and proposal of <i>Alloboseaceae</i> fam. nov. as a replacement name for the illegitimate family name <i>Boseaceae</i>. [PDF]

Int J Syst Evol Microbiol
Deshmukh UB, Oren A.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source