Results 271 to 280 of about 444,502 (344)

Comparative Genomics Reveals Conserved Bacteriocin-Associated Loci in <i>Lacticaseibacillus paracasei</i> Strains with Anti-MRSA Activity Isolated from Palmyra Palm Sugar. [PDF]

Antibiotics (Basel)
Romyasamit C, Surachat K, Pattaranggoon NC, Saki M, Sornsenee P.   +4 more
europepmc   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Evolutionary constraints and regulatory plasticity shape host specialization in the <i>Magnaporthe oryzae</i> species complex. [PDF]

Virulence
Hera MHR, Wu Q, Jibril SM, Li C, Wang Y.
europepmc   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Conserved assembly architecture of the essential herpesvirus packaging accessory factor. [PDF]

PLoS Pathog
Bailey EJ, Devarkar SC, Szczepaniak R, Meißner LM, Chen X, Wu C, Weller SK, Xiong Y, Didychuk AL.   +8 more
europepmc   +1 more source

Aberrant renal vessels crossing the ureter and the ureteropelvic junction: A retrospective computed tomography-based analysis of non-obstructed population. [PDF]

World J Radiol
Paschopoulos I, Triantafyllou G, Gondorf D, Arkoudis NA, Velonakis G, Mariorakis C, Lyrtzis C, Gyftopoulos K, Piagkou M.   +8 more
europepmc   +1 more source

Duplicated left renal vein with aberrant inferior drainage to left common iliac vein: A rare anomaly of left renal vein. [PDF]

Radiol Case Rep
Esfandiary R, Moghadam MBS, Sefidbakht S, Zahraei SAH, Pishdad P.   +4 more
europepmc   +1 more source