Results 101 to 110 of about 53,776 (316)

Breast cancer associated with an accessory nipple [PDF]

BMJ Case Reports, 2011
### Clinical presentation A 90-year-old female presented with a new mass along the anterolateral aspect of her chest wall. On clinical examination a hard, irregular subcutaneous lump inferior to the left inframammary fold and lateral to an accessory nipple was observed (figure 1).
Sabrina, Rajan, Kailas, Munot, James, Haselden   +2 more
openaire   +2 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Development of ListeriaBase and comparative analysis of Listeria monocytogenes [PDF]

, 2015
Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to ...
Ang, Mia Yang, Choo, Siew Woh, Dutta, Avirup, Heydari, Hamed, Mutha, Naresh VR, Siow, Cheuk Chuen, Tan, Mui Fern, Tan, Shi Yang, Wee, Wei Yee, Wong, Guat Jah   +9 more
core   +3 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

A rare case report of left axillary fibroadenoma in a 45-year-old woman [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Breast fibroadenoma in the axilla is a rare manifestation that consists of biphasic proliferation of fibromyxoid stroma without atypia or mitosis, with a glandular component consisting of two luminal and myoepithelial layers. In this study,
Mahsa Akbari Oryani, zahra Akhbari, Ehsan Hassanzadeh Haddad   +2 more
doaj   +1 more source

Inhibition of chemotherapy resistant breast cancer stem cells by a ROR1 specific antibody. [PDF]

, 2019
Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis.
Carson, Dennis A, Cui, Bing, Ghia, Emanuela M, He, Jinsong, Huang, Jiajia, Jiang, Wenqi, Kipps, Thomas J, Lam, Sharon, Lei, Yang, Messer, Karen, Parker, Barbara A, Schwab, Richard, Widhopf, George F, Wu, Liufeng, Yu, Jian, Zhang, Han, Zhang, Jianchao, Zhang, Suping   +17 more
core   +1 more source

Expression of CDK7, cyclin H and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor-positive breast cancer [PDF]

, 2016
PURPOSE: CDK-activation kinase (CAK) is required for the regulation of the cell-cycle and is a trimeric complex consisting of Cyclin Dependent Kinase 7 (CDK7), Cyclin H and the accessory protein, MAT1.
Abduljabbar R, Ali S, Buluwela L, Busonero C, Coombes RC, Ellis IO, Fuller-Pace FV, Gemma C, Gomm JJ, Győrffy, Balázs, Harrod A, Jerjees D, Jones JL, Lai CF, Magnani L, Patel H, Patel N, Periyasamy M, Rakha EA, Remenyi J, Shousha S, Smith S, Steel J   +22 more
core   +5 more sources

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Cancer Primitif d’un Sein Accessoire Infra Mammaire Chez un Homme : À Propos d’un Cas

Health Research in Africa
RÉSUMÉ Le cancer primitif du sein accessoire demeure une maladie rare souvent découverte à un stade tardif. Sa localisation axillaire sur la ligne lactée primitive est majoritaire et étayée par la littérature dans les deux sexes.
Ella-Ondo Timothée, Mba Angoue Jean-Marie Siégel, Nguema-Edzang Béatrice, Ernest Belembaogo   +3 more
doaj   +1 more source

Bilateral Ectopic Axillary Breast Tissue with Duct Ectasia: An Unexpected Occurrence

JK Science, 2023
Accessory breast tissue results due to failure of mammary streaks regression during embryogenesis. Patients present with palpable masses associated with cyclical pain in addition to cosmetic concerns.and this entity must be considered in differential ...
Hima Sree Edupuganti, Archana Shetty, Supriya T.R, Rohit Krishnappa, Nidha Gaffoor   +4 more
doaj