Results 261 to 270 of about 126,941 (295)

Detecting TP53 mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma

International Journal of Cancer, EarlyView.
What's New? High‐grade serous ovarian carcinoma is often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study introduces a novel TP53 mutation panel using unique molecular identifier‐based next‐generation sequencing for sensitive detection of high‐grade serous ovarian ...
Amanda Olsson Widjaja, Peter Micallef, Maria Lycke, Tobias Österlund, Manuel Luna Santamaría, Julia Hedlund Lindberg, Therese Carlsson, Ulf Gyllensten, Anders Ståhlberg, Benjamin Ulfenborg, Anna Linder, Karin Sundfeldt   +11 more
wiley   +1 more source

Pan-Mitogenome Construction, Intraspecific Variation, and Adaptive Evolution of the Plant Pathogenic Fungus <i>Claviceps purpurea</i>. [PDF]

Biology (Basel)
Ding M, Hu R, Jia J, Wei C, Cui Y, Liao H, Yang Z, Guo J, Ma Z, Wang Y.   +9 more
europepmc   +1 more source

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

iMeta, EarlyView.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou, Ming Li, Sujuan Zhang, Yu Liu, Zhixiang Yuan, Jiali Liu, Yanming Hu, Jingyang Wang, Chenghu Song, Shaowei Zhang, Lingyun Zhu, Jianzhong Shao, Aifu Lin, Wenjun Mao, Guangchuan Wang, Lvyun Zhu   +24 more
wiley   +1 more source

Comparative genomic analysis of native Bradyrhizobium spp. nodulating Retama dasycarpa in Moroccan semi-arid ecosystems: insights into symbiotic diversity and environmental adaptation. [PDF]

BMC Genomics
Lamrabet M, Missbah El Idrissi M.
europepmc   +1 more source

PD‐1/PD‐L1 in Hepatocellular Carcinoma (2014–2024): A Combined Macro and Micro Analysis of Immunotherapy Implications

iNew Medicine, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) represents a significant global health issue, with the PD‐1/PD‐L1 axis serving a pivotal target for immunotherapy in this malignancy. However, a comprehensive bibliometric analysis of PD‐1/PD‐L1 research in HCC is lacking.
Xingyu Zhu, Lin Tang, Hongyan Li, Hao Li, Jiamei Wang   +4 more
wiley   +1 more source

Phenotypic and genotypic characterization of ST103 serotype Ia Streptococcus agalactiae isolated from bovine mastitis in China. [PDF]

BMC Microbiol
Wang Y, Meng S, Bahetijiang H, Li H, Wang T, Assabayev T, Barkema HW, Kastelic JP, Han B, Deng Z.   +9 more
europepmc   +1 more source

Discontinuous template switching generates coronavirus subgenomic RNAs from the 3' viral genome end by 5' to 3' transcription. [PDF]

J Virol
Brant AC, Hu Z, Chen AZ, Majerciak V, Yewdell J, Zheng Z-M.   +5 more
europepmc   +1 more source

Genomic diversity, antimicrobial resistance and dissemination of <i>Serratia marcescens complex</i> in patients admitted to ICUs. [PDF]

Front Cell Infect Microbiol
Zhu W, Chen X, Shen H, Wei M, Yang C, Gu L.   +5 more
europepmc   +1 more source

Data Sheet 1_Geographic diversity of the Streptococcus equi subsp. equi accessory genome: implications for vaccines and global surveillance.csv

Lingyu He (109344), Nwai Oo Khine (9619448), Jeongmin Song (69898), Celine Loubière (22701986), Patrick Butaye (151688)   +4 more
openalex   +1 more source

Five-Year (2017-2022) Evolutionary Dynamics of Human Coronavirus OC43 in Southern France Based on Whole Genome Next-Generation Sequencing. [PDF]

J Med Virol
Houmadi H, Boschi C, Lefebvre M, Le Targa L, Py J, Lagier JC, Lesage L, Fantini J, Morand A, La Scola B, Colson P.   +10 more
europepmc   +1 more source