Results 251 to 260 of about 2,510,704 (333)

The Molecular Basis of Amino Acids Sensing

open access: yesAdvanced Science, EarlyView.
Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang   +3 more
wiley   +1 more source

Secondary Electron Hyperspectral Imaging of Carbons: New Insights and Good Practice Guide

open access: yesAdvanced Science, EarlyView.
Secondary hyperspectral imaging of carbon surfaces is assessed with reference materials and in comparison to standard spectroscopies. Characterization of functional carbon materials from battery research reveals otherwise inaccessible information about the distribution of sp2 and amorphous carbon, as shown in graphite anode and carbon coated lithium ...
James F. Nohl   +22 more
wiley   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

open access: yesAdvanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu   +17 more
wiley   +1 more source

Targeted Dual‐Responsive Liposomes Co‐Deliver Jolkinolide B and Ce6 to Synergistically Enhance the Photodynamic/Immunotherapy Efficacy in Gastric Cancer through the PANoptosis Pathway

open access: yesAdvanced Science, EarlyView.
Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma   +14 more
wiley   +1 more source

Usefulness of omnipolar technology near field for accessory pathway ablation through the coronary sinus. [PDF]

open access: yesHeartRhythm Case Rep
Mizutani Y   +5 more
europepmc   +1 more source

Suppressing Colloidal Quantum Dot Multimer Fusion Leads to High‐Performance InSb Infrared Photodetectors

open access: yesAdvanced Science, EarlyView.
This work shows that the fusion of InSb colloidal quantum dots (CQDs) leads to the formation of band‐tail trap states that are detrimental to the performance of optoelectronic devices. These results highlight the critical role of suppressing band‐tail trap states and passivating surface defects in enhancing device performance and motivate toward the ...
Lucheng Peng   +6 more
wiley   +1 more source

Glucose‐Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia

open access: yesAdvanced Science, EarlyView.
The work constructs a glucose‐triggered gel for diabetic abscess treatment. The results demonstrate that the gel catalyzes glucose into oxygen, alleviates the hypoxia, and ensures sufficient ROS generation to combat pathogenic bacteria. Simultaneously, borneol within the gel can enhance the antibacterial activity of ROS and alleviate pain in patients ...
Bin Huang   +12 more
wiley   +1 more source

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