Results 31 to 40 of about 83,161 (306)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Multiple Arrhythmogenic Substrate for Tachycardia in a Patient with Frequent Palpitations

Indian Pacing and Electrophysiology Journal, 2005
We report a 26-year-old woman with frequent episodes of palpitation and dizziness. Resting electrocardiography showed no evidence of ventricular preexcitation.
Majid Haghjoo, Arash Arya, Mohammadreza Dehghani, Zahra Emkanjoo, Amirfarjam Fazelifar, MohammadAli Sadr-Ameli   +5 more
doaj  

Landiolol, an intravenous β1‐selective blocker, is useful for dissociating a fusion of atrial activation via accessory pathway and atrioventricular node

Journal of Arrhythmia, 2023
Introduction During ventricular pacing, a fusion of atrial activation may occur owing to the simultaneous retrograde conduction of the atrioventricular (AV) node and accessory pathway (AP), potentially leading to an inaccurate mapping of the atrial AP ...
Takahiko Kinjo, Masaomi Kimura, Noriyoshi Kaname, Daisuke Horiuchi, Taihei Itoh, Yuji Ishida, Kimitaka Nishizaki, Yuichi Toyama, Shingo Sasaki, Hirofumi Tomita   +9 more
doaj   +1 more source

PO-04-089 AN UNUSUAL CASE OF A RIGHT ATRIAL APPENDAGE TO POSTERIOR RIGHT VENTRICULAR OUTFLOW TRACT ACCESSORY PATHWAY [PDF]

, 2023
Peter Rothstein, Stephanie C. Fuentes Rojas, Amish S. Dave   +2 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Incessant Narrow QRS Complex Tachycardia in a Patient With a Prior Ablation History

Annals of Noninvasive Electrocardiology
Introduction A 30‐year‐old woman with a history of prior ablation for a concealed left posteroseptal accessory pathway (AP) presented with incessant narrow QRS tachycardia, highlighting a rare complication of incomplete AP ablation.
Yi Liu, Yuwei Chen, Xiangbin Xiao, Xiaobo Pu   +3 more
doaj   +1 more source

11-year follow-up outcomes of catheter ablation of para-hisian accessory pathways [PDF]

, 2021
Lili Xu, Q Chen, Tie Zou, Kuan Cheng, Yunlong Ling, Ye Xu, Yuk Kam Pang, G Liu, Wenqing Zhu, Junbo Ge   +9 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transcatheter ablation of the posteroseptal accessory pathways [PDF]

Acta Medica Iranica, 2000
Transcatheter ablation of atrioventricular accessory pathway is the therapy of choice in symptomatic patients. The ablation of posteroseptal accessory pathways thas some important points due to its anatomical location.
Moghaddam M, Yamini Sharif A   +1 more
doaj   +1 more source