Results 51 to 60 of about 83,947 (312)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Fasciculoventricular pathways—A rare and innocent variant: A Retrospective study focusing on clinical and electrophysiologic characteristics

open access: yesAnnals of Noninvasive Electrocardiology, 2022
Background Fasciculoventricular pathways (FVPs) are variants of pre‐excitation syndrome which were investigated insufficiently because of its rarity. Objective This report aimed to represent one of the largest series of FVP, focusing on its clinical and ...
Suat Gormel, Salim Yasar
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Real analyticity of accessory parameters [PDF]

open access: yesarXiv, 2020
We consider the problem of the real analytic dependence of the accessory parameters of Liouville theory on the moduli of the problem, for general elliptic singularities. We give a simplified proof of the almost everywhere real analyticity in the case of a single accessory parameter as it occurs e.g.
arxiv  

Establishment and biological characterization of radioresistant colorectal cancer cell lines

open access: yesFEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu   +10 more
wiley   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

open access: yesFEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee   +5 more
wiley   +1 more source

On the perfomance of a photosystem II reaction centre-based photocell [PDF]

open access: yesarXiv, 2016
The photosystem II reaction centre is the photosynthetic complex responsible for oxygen production on Earth. Its water splitting function is particularly favoured by the formation of a stable charge separated state via a pathway that starts at an accessory chlorophyll.
arxiv  

Isomonodromy sets of accessory parameters for Heun class equations [PDF]

open access: yesarXiv, 2021
In this paper, we consider the monodromy and, in particularly, the isomonodromy sets of accessory parameters for the Heun class equations. We show that the Heun class equations can be obtained as limits of the linear systems associated with the Painlev\'{e} equations when the Painlev\'e transcendents go to one of the actual singular points of the ...
arxiv  

A recurrent concealed parahisian accessory pathway [PDF]

open access: yesClinical Case Reports, 2018
Key Clinical MessageThis case demonstrates the interest of ablating in the aortic root in case of resistant parahisian accessory pathways with failure of the right side approach. Failure on the right side may be due to fear of creating an AV block of failure to ablate critical fibers in the parahisian position.
Thierry Verbeet   +2 more
openaire   +3 more sources

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

open access: yesFEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu   +4 more
wiley   +1 more source

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