Results 121 to 130 of about 2,064,850 (237)

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

open access: yesThe FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova   +5 more
wiley   +1 more source

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

open access: yesThe FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna   +17 more
wiley   +1 more source

Movimiento, operación, acción y producción [PDF]

open access: yes, 2004
En este artículo se parte de la distinción aristotélica de cuatro formas fundamentales de acción: enérgeia-kínesis (de la Metafisica) y praxis—potesis (de la Etica) y de las aportaciones de L.
Bastons, M. (Miquel)
core  

Acclimatization length and post‐release spatial cohesion in translocated Griffon Vultures (Gyps fulvus)

open access: yesIbis, EarlyView.
Translocations are often used in the conservation of large raptors, including Old World vultures. Different release methods are usually assessed by comparing the movement patterns and survival of released individuals. However, these approaches fail to capture the gregarious behaviour of many vulture species.
Jacopo Cerri   +11 more
wiley   +1 more source

AMIGHETTI SOBRE LAS TABLAS

open access: yesKáñina, 2012
Unimos nuestros talentos, nuestra imaginación y, en un diálogo permanente de equipos, construimos un mundo nuevo para celebrar a Francisco Amighetti, ese extraordinario artista que nos regala, con creatividad y magia, su lectura de la realidad.
María Pérez Yglesias
doaj  

Psychometric validation of the Spanish version of the parent‐reported developmental profile 3 (DP‐3)

open access: yesJournal of Neuropsychology, EarlyView.
Abstract Neurodevelopmental assessment in childhood is essential in educational, clinical, and research contexts to establish benchmarks and detect early signs of neurodevelopmental disorders. The Developmental Profile 3 (DP‐3) is a parent‐reported screening tool for measuring neurodevelopment in the general population, though its Spanish adaptation ...
Pol Jimenez‐Arenas   +11 more
wiley   +1 more source

Performing Micro‐Role Transitions in Open Strategy

open access: yesJournal of Management Studies, EarlyView.
Abstract Open strategy (OS) requires contributors with a variety of functional backgrounds to episodically perform a strategy role in addition to their functional responsibilities. These actors engage in micro‐role transitions as they temporarily shift from one role to another.
Anna Plotnikova   +2 more
wiley   +1 more source

Acción social y pueblo gitano [PDF]

open access: yes, 2003
.This currently much more complex to refer to the Gypsy people than it may have beenfive or ten years ago. Neither non-Gypsy nor Gypsy society is the same as then. Globalisation and its consequences have also reached smaller cultural groups.
Llopis, Rosa
core  

The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition

open access: yesNew Phytologist, EarlyView.
Summary Iron (Fe) is a transition metal necessary for achieving essential physiological processes throughout the plant lifecycle. In Arabidopsis thaliana, secreting Fe‐mobilizing coumarins (FMC) is a key mechanism enabling roots to acquire nonbioavailable Fe present in soils.
Shunsuke Watanabe   +7 more
wiley   +1 more source

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