Results 141 to 150 of about 128,335 (267)

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

Intelligent identification of causative factors and construction of accident chain for crane operation. [PDF]

Sci Rep
Zhao J, Cui H, Hu Z, Kang R, Li J, Zhang J.   +5 more
europepmc   +1 more source

Applying machine learning to pharmacovigilance data: A proof‐of‐concept study

British Journal of Clinical Pharmacology, EarlyView.
Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus, Pauline Schiro, Jean‐Luc Faillie, Romane Freppel, Johana Béné, Claire de Canecaude, François Montastruc   +6 more
wiley   +1 more source

Occupational safety in coal logistics: a systematic review of systemic risks and human factors. [PDF]

Front Public Health
Abdullah WPAW, Arifin K, Juhari ML, Aiyub K, Abas A.   +4 more
europepmc   +1 more source

Decadal stability of radiocesium inventories and soil to tree transfer in forests affected by the Fukushima nuclear accident. [PDF]

Sci Rep
Sakashita W, Imamura N, Ohashi S, Komatsu M, Araki MG, Saito S, Kajimoto T, Hashimoto S, Manaka T, Sakata T, Ohmae Y, Miura S, Shinomiya Y.   +12 more
europepmc   +1 more source

The quality of interaction with children in collective play: Children's agency

British Educational Research Journal, EarlyView.
Abstract There is a growing body of studies on increasing the quality of infant–toddler education and care. Yet little attention has been directed towards how to bring toddlers' agency and perspective to their personally meaningful learning in collective play.
Liang Li
wiley   +1 more source

Delayed Manifestations of a Case of Blunt Chest Wall Trauma-Induced Pseudoaneurysm of the Mitral-Aortic Intervalvular Fibrosa: A Case Report and Literature Review. [PDF]

Clin Case Rep
Mirzaei A, Attar A, Moaref A, Amirghofran AA.   +3 more
europepmc   +1 more source

Exploring the early observations of parents supporting their children with school attendance problems (SAPs): A co‐produced study

British Educational Research Journal, EarlyView.
Abstract School Attendance Problems (SAPs) represent a significant challenge requiring early identification and intervention. Current service provision often does not recognise early indicators that parents observe, creating gaps between when initial concerns are raised and formal support is provided.
Tereza Aidonopoulou‐Read, Michelle Pyer, Beth Bodycote, Jackie Campbell, Kirsteen Pyer   +4 more
wiley   +1 more source

Microbially Induced Corrosion: A Hidden Risk in Industrial Accidents. [PDF]

ACS Omega
Vítěz T, Kotek L, Černý M, Hanišáková N, Vítězová M, Trávníček P.   +5 more
europepmc   +1 more source

‘I was treated as a deficit’: Immigrant teachers' career progression in Australia

British Educational Research Journal, EarlyView.
Abstract Immigrant teachers have long been recruited through skilled and employer‐sponsored migration schemes to address teacher shortages in Australia, yet their career trajectories remain constrained by systemic inequities that limit their integration and professional development opportunities.
Ching Ting Tany Kwee, Hoa Thi Mai Nguyen, Tony Loughland   +2 more
wiley   +1 more source