Results 141 to 150 of about 850,892 (286)
Study of adhesion and cohesion in vacuum Final report [PDF]
Vacuum metal-metal bonding tests to determine conditions of accidental adhesion of spacecraft structural ...
Mc Intyre, D. V., Winslow, P. M.
core +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
Home is Where the Hurt is: An Econometric Analysis of Injuries Caused By Spousal Assault [PDF]
Using data on injuries presenting at the emergency departments of participating hospitals in the Australian state of Queensland we examine the nature of injuries resulting from spousal assault and compare them to injuries from nonspousal assault and ...
Borooah, Vani, Mangan, John
core +1 more source
Advanced Science, EarlyView.Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl +27 more
wiley +1 more source
Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy
Advanced Science, EarlyView.This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge +14 more
wiley +1 more source
Advanced Science, EarlyView.Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong +6 more
wiley +1 more source
Accidental Childhood Poisoning
Journal of Rawalpindi Medical College, 2014 Background: To study frequency of different poisonings in children in tertiary care hospital. Methods : In this cross sectional study 81 children under 12 years presenting with signs and symptoms of poisoning were included.
Bilal Ahmad
doaj