Results 251 to 260 of about 831,122 (329)

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

Advanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang, Junhua Yun, Guoyan Zhang, Hossain M. Zabed, Yuehui Tian, Xinrui Tang, Jia Li, Xianghui Qi   +7 more
wiley   +1 more source

Alternative Models for Anticancer Drug Discovery From Natural Products Using Binary Tumor‐Microenvironment‐on‐a‐Chip

Advanced Science, EarlyView.
This study presents a binary tumor‐microenvironment‐on‐a‐chip (T‐MOC) system incorporating multicellular tumor spheroids (MCTs) as an alternative preclinical platform to evaluate the efficacy of anticancer natural products. The T‐MOC model reproduces in vivo drug delivery barriers and physiological conditions, enabling morphological analysis to predict
Youngwon Kim, Si Hyeon Chae, Dahae Lee, Bum Soo Lee, Jiseok Lim, Hyo‐Il Jung, Ki Hyun Kim, Bongseop Kwak   +7 more
wiley   +1 more source

Advanced Brain‐on‐a‐Chip for Wetware Computing: A Review

Advanced Science, EarlyView.
Exploring Low‐Power, Beyond‐Silicon‐Computing Bio‐Computing: Brain‐on‐a‐Chip Technology. This article reviews the applications of Brain‐on‐a‐Chip in Wetware Computing, including in vitro‐cultured brain organoids, microelectrode arrays, electrophysiological interfaces, and microfluidic platforms, as well as data processing methods. It also looks forward
Shangchen Li, Yaoyao Liu, Sihan Hua, Yu Wang, Shutong Sun, Longhui Jiang, Chengji Lu, Juntao Liu, Huaizhang Shi, Pei Wu, Xinxia Cai, Jinping Luo   +11 more
wiley   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface

Advanced Science, EarlyView.
Drop‐on‐demand printing is used to replicate the spatial compartmentalization of the breast cancer‐host interface. Hydrogel confinement affects phenotypic changes in cells at the spheroid interface that drives a two‐fold increase in chemotherapeutic resistance compared to control unconfined spheroids.
Bram G. Soliman, Peilin Tian, Jiuyu Cui, Kristopher A. Kilian, J. Justin Gooding   +4 more
wiley   +1 more source

Liquid Metal Printed Zinc Tin Composite Oxide Nanosheets: A Platform for Multifunctional Sensing at Room Temperature

Advanced Science, EarlyView.
This work introduces a vacuum‐free liquid metal printing approach to create ultrathin zinc–tin composite oxide nanosheets. The material shows strong UV light responsiveness and high sensitivity to ammonia gas at room temperature, highlighting the potential of mixed metal oxides for advanced environmental sensors and optoelectronic device technologies ...
Vaishnavi Krishnamurthi, Hamidah Alluhaybi, Pargam Vashishtha, Xiangyang Guo, Huy Hoang Nguyen, Javad Khosravi Farsani, Ali Zavabeti, Sindhu Priya Giridhar, Azmira Jannat, Shimul Kanti Nath, Aaron Elbourne, Sumeet Walia, Torben Daeneke, Ylias Sabri, Chung Kim Nguyen, Nitu Syed   +15 more
wiley   +1 more source

Pediatric methamphetamine poisoning: Case report of a one-year-old child. [PDF]

Ulus Travma Acil Cerrahi Derg
Barut E, Barut K.
europepmc   +1 more source

Birds of California; an introduction to more than three hundred common birds of the state and adjacent islands, with a supplementary list of rare migrants, accidental visitants, and hypothetical subspecies, by Irene Grosvenor Wheelock ... with ten fullpage plates and seventy-eight drawings in the text by Bruce

, 1912
Irene Grosvenor Wheelock
openalex   +2 more sources

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Advanced Science, EarlyView.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan   +7 more
wiley   +1 more source

A Systematic Review and Meta-Analysis on Long-Term Exposure to Particulate Matter and All-Cause and Cause-Specific Mortality in the Asia-Pacific States. [PDF]

J Korean Med Sci
Oh J, Hevia-Ramos G, Ha E, Hong YC, Kim H, Lim YH.   +5 more
europepmc   +1 more source