Results 31 to 40 of about 172,390 (262)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Accidental actions values and combinations for key-elements checking [PDF]
E3S Web of Conferences, 2020 In the case of accidental design situations, if accidental actions can be identified, one of the possible design strategies is checking the key element. This strategy minimizes the possibility of local failure and subsequent progressive collapse.
Tur Viktar +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BMJ Open, 2021 Objective Few studies have analysed accidental maternal deaths. This study analysed the basic situation and classification of maternal accidental deaths and compared the differences between urban and rural areas.Design A cross-sectional study on ...
Fanjuan Kong +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Pattern of Acute Pediatric Poisoning at Assiut University Hospitals: Prospective Study [PDF]
Zagazig Journal of Forensic Medicine and ToxicologyBackground: Child poisoning is a serious health issue that affects both developed and developing nations, and it is a key fBackground: Child poisoning is a serious health issue that affects both developed and developing nations, and it is a key factor in
Safaa George +2 more
doaj +1 more source
Pakistan Armed Forces Medical Journal, 2021 Objective: To determine the commonest site of non-suicidal self-inflicted firearm wound in comparison with accidental firearm wounds. Study Design: Cross sectional study.
Syed Shehzad Hasnain +5 more
doaj
The Question of ‘How Are Synthetic A Priori Judgments Possible’ in Contemporary Islamic Philosophy [PDF]
Pizhūhish/hā-yi Falsafī- KalāmīAccording to Kant, the lack of progress in metaphysics is due to the fact that philosophers tried to solve metaphysical problems without examining the limits of our reason, and the outcome of these endeavors has been a dogmatic metaphysics fraught with ...
ُSeyed Ali Taheri Khorramabadi
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source