Results 91 to 100 of about 668,230 (326)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Patient and system factors associated with unassisted and injurious falls in hospitals: an observational study

BMC Geriatrics, 2019
Background Unassisted falls are more likely to result in injury than assisted falls. However, little is known about risk factors for falling unassisted. Furthermore, rural hospitals, which care for a high proportion of older adults, are underrepresented ...
Dawn M. Venema, Anne M. Skinner, Regina Nailon, Deborah Conley, Robin High, Katherine J. Jones   +5 more
doaj   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Thermally Induced Creep and Viscoelastic Behavior of Copper Micropillar Arrays

Advanced Science, EarlyView.
Copper micropillar arrays are fabricated by electrodeposition within through‐glass‐via, and their thermally induced time‐dependent deformation is quantified. Nanoindentation creep, EBSD, and TEM reveal a heat‐treatment‐driven transition between grain‐boundary‐mediated deformation and dislocation‐dominated creep, while Kelvin modeling captures ...
Miao Wang, Jihua Zhang, Libin Gao, Hongwei Chen, Wenbo Luo, Wenlei Li, Mingcheng Chen, Mengru Li, Dongbin Wang, Shuang Li, Ting Liu, Xingzhou Cai, Yong Li, Bin Peng, Wanli Zhang   +14 more
wiley   +1 more source

Cognitive status in elderly patients with hip fracture in western Romania [PDF]

Research and Clinical Medicine, 2016
OBJECTIVES The aim of this study was to evaluate the cognitive status of geriatric patients hospitalised for fall-related MATERIALS AND METHODS 100 patients aged ≥65 years, successively admitted to the Orthopedic Units of the Emergency County ...
Claudia Cristina Vasilian1,, Simona Claudia Tamasan2, , Manuel Oprea1,, Dan V. Poenaru1   +3 more
doaj  

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Domiciliary environmental risk factors for accidental falls among community‐living older persons: A prospective 12‐month study

, 2015
Background: Falls are common internationally among the elderly. This study examined domiciliary environmental risk factors attributable to accidental falls among community‐living older persons living in highrise buildings in Hong Kong.
K. Fong, A. M. Siu, P. Ma, Kenneth Ka‐Yu Au Yeung, P. P. Sze, C. Chan   +5 more
semanticscholar   +1 more source

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source

Integrated Ultrasound Device for Precision Bladder Volume Monitoring via Acoustic Focusing and Machine Learning

Advanced Science, EarlyView.
We present a conformable wearable ultrasound patch for noninvasive bladder volume monitoring. A flexible PZT array combined with a concave acoustic lens concentrates acoustic energy and improves depth selectivity through the anterior pelvic wall.
Long Long Cao, Feng Wen Wang, Jingwei Xue, Fulei Liu, Ming Liang Jin   +4 more
wiley   +1 more source

Identifying determinants for falls among Iranian older adults: insights from the Bushehr Elderly Health Program

BMC Geriatrics
Background Falls are a common cause of fractures in older adults. This study aimed to investigate the factors associated with spontaneous falls among people aged ≥ 60 years in southern Iran.
Kazem Khalagi, Amir Human Hoveidaei, Hani AziziKia, Amirali Karimi, Reza Sattarpour, Noushin Fahimfar, Mahnaz Sanjari, Mohammad Javad Mansourzadeh, Iraj Nabipour, Bagher Larijani, Afshin Ostovar   +10 more
doaj   +1 more source