British Journal of Clinical Pharmacology, EarlyView.Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley +3 more
wiley +1 more source
Accidents from falls among hospitalized patients in Emergency Units: a multicenter study. [PDF]
Rev Bras EnfermGiaquinto BCD +5 more
europepmc +1 more source
Applying machine learning to pharmacovigilance data: A proof‐of‐concept study
British Journal of Clinical Pharmacology, EarlyView.Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus +6 more
wiley +1 more source
Paediatric clonidine medication errors: Findings from a multicentre French study
British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to describe the characteristics of medication errors involving clonidine in paediatric patients and reported to French Network of Pharmacovigilance and Poison Control Centres. Methods This retrospective observational study analysed clonidine‐related medication errors reported between 1985 and June 2024 in patients under 12 years ...
Eve‐Marie Thillard +8 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley +1 more source
Knowledge, attitudes and practices of pregnant women for preventing risks and accidents with their newborns: cross-sectional study, Recife, 2024. [PDF]
Epidemiol Serv SaudeBastos MEDS +4 more
europepmc +1 more source
Benzodiazepines use in primary care England: Prescribing patterns and adverse consequences
British Journal of Clinical Pharmacology, EarlyView.Aims Benzodiazepines (BZDs) are commonly prescribed for anxiety and insomnia but carry risks such as dependence, adverse drug reactions (ADRs) and mortality. Despite deprescribing efforts, the influence of recent prescribing trends, COVID‐19 and adverse outcomes on prescribing patterns in England remains uncertain.
Alvina Chaudhry +3 more
wiley +1 more source
Can nursing contribute to reducing mortality from land transport accidents? [PDF]
Rev Bras EnfermLima RS, Rodrigues AA.
europepmc +1 more source
Educational strategies for preventing accidents in childhood: a systematic review. [PDF]
Cad Saude PublicaLaguna GGC +6 more
europepmc +1 more source
[Towards a social and food justice for agricultural day laborers with internal migration in Mexico]. [PDF]
Cad Saude PublicaVillalobos-Pérez AG +4 more
europepmc +1 more source