Results 91 to 100 of about 157,454 (283)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
El rol de los docentes co-formadores en el proceso de prácticas del Profesorado en Historia
Clio y Asociados, 2019 In the teaching career in History of the Autonomous University of Entre Ríos, the teaching practices are carried out at secondary and higher levels, so we are interested in observing, analyzing and understanding the processes that involve the practicing ...
Verónica Gatti +2 more
doaj +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
An examination of the keyboard technique of Bach, Haydn, Chopin, Scriabin and Prokofiev [PDF]
, 2016 Master's Project (M.Mu.) University of Alaska Fairbanks, 2016In this research paper, I will explore the keyboard technique of each composer presented in my recital: J.S.
Hays, Jonathan K.
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Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
LEÇONS D'UNE EXPERIENCE DE RECHERCHE-ACTION APPLIQUEE A L'ACCOMPAGNEMENT [PDF]
, 2010 N° ISBN - 978-2-7380-1284-5International audienceThe communication analyzes how was elaborate and set up an action-research applied to pluriactivity accompaniement in Haut-Languedoc (Hérault), and questions the double posture of the researcher placed in ...
Tallon, Hélène
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Protective coating for gabion wires against weathering elements and site conditions [PDF]
, 2018 Gabions are one of the most essential elements in the geotechnical field for their versatility and strength in slope stabilization. According to BS 8002:2015, gabions are rectangular large cages or baskets made of either steel wire or square welded mesh,
Abdul Rashid, Azrin Hani +2 more
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