Results 91 to 100 of about 157,476 (282)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Encoding Spatial Experience in Garhwali Popular Music Cassettes [PDF]

, 2018
Connections between particular sounds and geographically conceived places/spaces seems to be a recurrent part of many repertoires in different parts of the Himalaya. A number of examples exist in which ritual repertoires are linked to pilgrimage pathways,
Alter, Andrew B
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Welcome Guide for families at the delivery area

NURE Investigación, 2013
Childbirth is a natural and physiological process which involves pregnant women and their loved ones. This is the reason why health professionals should always implicate the family in our care.In our service, the delivery area, we consider the need to ...
Ana María Torres Fuentes, Mª José Quesada Porcel, Óscar Antonio Villalba Merchán   +2 more
doaj  

Real-Time Audio-to-Score Alignment of Music Performances Containing Errors and Arbitrary Repeats and Skips

, 2015
This paper discusses real-time alignment of audio signals of music performance to the corresponding score (a.k.a. score following) which can handle tempo changes, errors and arbitrary repeats and/or skips (repeats/skips) in performances.
Nakamura, Eita, Nakamura, Tomohiko, Sagayama, Shigeki   +2 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Protective coating for gabion wires against weathering elements and site conditions [PDF]

, 2018
Gabions are one of the most essential elements in the geotechnical field for their versatility and strength in slope stabilization. According to BS 8002:2015, gabions are rectangular large cages or baskets made of either steel wire or square welded mesh,
Abdul Rashid, Azrin Hani, Chee Ming, Chan, Keong, Tan Kok   +2 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

LEÇONS D'UNE EXPERIENCE DE RECHERCHE-ACTION APPLIQUEE A L'ACCOMPAGNEMENT [PDF]

, 2010
N° ISBN - 978-2-7380-1284-5International audienceThe communication analyzes how was elaborate and set up an action-research applied to pluriactivity accompaniement in Haut-Languedoc (Hérault), and questions the double posture of the researcher placed in ...
Tallon, Hélène
core   +1 more source