Results 61 to 70 of about 3,663 (299)

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Accompagner un accouchement sans péridurale : étude qualitative sur l’expérience professionnelle des sages-femmes à l’hôpital de Romans-sur-Isère [PDF]

, 2022
Objectives: The aim of this study was to identify the obstacles and levers met by midwives when supporting a childbirth without epidural at the hospital, and also to highlight its impact on the midwives’ professional practice and experience. Methods : It
Hermier, Maya
core  

British National Formulary Guidance on prescribing in pregnancy: A descriptive cross‐sectional study

British Journal of Clinical Pharmacology, EarlyView.
Aim To assess how well pregnancy‐specific guidance within the British National Formulary supports healthcare professionals to facilitate safe and effective medication use. Methods We performed a manifest content analysis of the text of all pregnancy sections within British National Formulary drug monographs, with inductive and iterative coding.
Hannah Johnson, Cleodie Swire, Lakshiv Dhingra, Toqa El‐Nahhas, Michelle Essiam, Salma Muse, Maria Tonkova, Nazmin Begum, Joan Morris, Emma Baker   +9 more
wiley   +1 more source

Accouchement dans l’eau et issue périnéale [PDF]

, 2022
Objectives: To study the impact of water birth on the perineal state. Material and methods : This was a retrospective, quantitative, cohort study, with one exposed subject for two unexposed subjects.
Sublet, Clémentine
core  

Pregnancy‐related effect on elexacaftor, tezacaftor and ivacaftor pharmacokinetics in women with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Aim The number of pregnancies among women with cystic fibrosis (wwCF) has steadily increased over the past decade. However, the pharmacokinetics (PK) of elexacaftor–tezacaftor–ivacaftor (ETI) during gestation remains uncharacterized, despite its widespread use in this population.
Paulette Magnas, Naim Bouazza, Frantz Foissac, Saïk Urien, Léo Froelicher‐Bournaud, Gabrielle Lui, Victoria Guillemart, Nicolas Carlier, Jennifer Da Silva, Johanna Fesenbeckh, Reem Kanaan, Isabelle Honoré, Clémence Martin, Jean‐Marc Treluyer, Vassilis Tsatsaris, Pierre‐Régis Burgel, Sihem Benaboud   +16 more
wiley   +1 more source

Rupture de la rate au cours de L'accouchement : à propos d'un cas

The Pan African Medical Journal, 2011
La rupture de rate est une extrême urgence chirurgicale abdominale qui met très rapidement en jeu le pronostic vital. Les étiologies fréquemment retrouvées sont les traumatismes abdominaux par contusions ou plaies pénétrantes. La survenue d'un rupture de
Houda Elbahraoui, Hanane Bouziane, Jamila Akrouch, Amina Lakhdar, Driss Ferhati   +4 more
doaj   +1 more source

Condylome acumine vulvaire geant au cours de la grossesse

PAMJ Clinical Medicine, 2020
Les condylomes acuminés ano-génitaux externes liés à l´infection à papillomavirus sont fréquents pendant la grossesse avec un risque de transmission faible au moment de l´accouchement. Nous rapportons un cas de condylome acuminé géant surinfecté au cours
Hadiza Moutari Soulé, Fatima Zohra Fdili Alaoui   +1 more
doaj   +1 more source

Effect of esomeprazole on the pharmacokinetics of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader, in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study is to evaluate the effects of multiple doses of esomeprazole, a strong proton pump inhibitor and acid‐reducing agent, on the pharmacokinetics and safety of vepdegestrant, a PROteolysis TArgeting Chimera oestrogen receptor degrader.
Lana Tran, Naihan Chen, Jennifer A. Winton, Kyle T. Matschke, Smita P. Goodman, Kimberly C. Lee, Yuanyuan Zhang, Weiwei Tan   +7 more
wiley   +1 more source

DU CONGÉ DE MATERNITÉ : ANALYSE CRITIQUE DES ARTICLES 129 ET 130 DU CODE DU TRAVAIL CONGOLAIS [PDF]

Cahiers Africains des Droits de l’Homme et de la Démocratie ainsi que du Développement Durable
Les articles 129 et 130 du Code du travail congolais consacrent, à leurs premiers alinéas, le droit de la femme salariée au congé de maternité. Toutefois, de leur analyse critique, il nous semble que ces deux textes soulèvent, dans leur ensemble, trois ...
Martin KONYI CITENGA
doaj