Results 71 to 80 of about 2,115,210 (258)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019 The goal of this article is to answer the question: what actions in the area of communicating online social presence increase the consumer's clickthroughs and online sales of the promoted offer in the affiliate marketing context.
Martyna Michalik, Ryszard Kłeczek
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Understanding key account management
, 2011 This document is presented in three parts, i.e. Part 1, ‘The context of ‘Understanding Key Account Management’, positions the portfolio of work in terms of its contribution to knowledge within the literature of Key Account Management and its underlying ...
Woodburn, Diana
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Московский журнал международного праваINTRODUCTION. This article examines a pressing issue of human-rights protection arising in the inheritance of digital objects that have no economic value or have an indeterminate economic value and are closely linked with the decedent’s private life ...
A. G. Shipikova
doaj +1 more source
Социальная психология и общество, 2019 The article is devoted to quite relevant issues today, which are discussed at different levels of research in the field of management psychology, namely, the development of psychological profiling algorithms based on the analysis of activity in social ...
Ilyin V.A., Mikhailova E.A.
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Legal regime of account: Approaches to defining a virtual object of law
Цифровое правоThis article examines issues that have been insufficiently developed in Russian jurisprudence concerning the legal nature of accounts in information systems (on the example of social networks) and the legal status of persons who have a legitimate ...
V. O. Panin
doaj +1 more source