Results 241 to 250 of about 3,350,227 (307)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Heterogeneous survival impact of immune-related adverse events in US veterans. [PDF]

J Immunother Cancer
Rehmani S, Higgins LM, Brinzevich D, Falvello V, Strohbehn GW, Dykstra M, Elliott D, Ramnath N, Bryant AK.   +8 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A hybrid machine learning and explainable AI framework for optimizing risk-based authentication. [PDF]

PLoS One
Sasikumar K, Nagarajan S.
europepmc   +1 more source

Quality assessment of dry eye educational videos on Xiaohongshu and differences by uploader type. [PDF]

Front Med (Lausanne)
Niu S, Han B, Liu X, He H, Wu Y, Sun D, Qu L.   +6 more
europepmc   +1 more source

Vegetation-Atmosphere Water Deficit as the Primary Control on Alpine Steppe and Forest Coverage: An Empirical Assessment from the Altay Mountains, Northwestern China. [PDF]

Biology (Basel)
Xu Q, Xu Y, Cui D, Lin T, Miao Z, Gong Y, Aili A, Bakayisire F.   +7 more
europepmc   +1 more source

Instagram Video Engagement in Medical Education: Cross-Sectional Study. [PDF]

JMIR Med Educ
Kemppainen A, Nuutinen H, Koljonen V, Kulmala P.   +3 more
europepmc   +1 more source

Spatial access to inpatient mental health services in Kerala, India: a Geospatial Information System-based travel-time isochrone analysis. [PDF]

BMJ Open
Varughese DT, Thomas JE, Paulose JK.
europepmc   +1 more source

Public accountability: a summary analysis

, 2016
openaire   +2 more sources