Results 81 to 90 of about 497,815 (308)

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Fiscal Year 2010 Performance and Accountability Report

, 2008
Other written product issued by the Government Accountability Office with an abstract that begins "Presented is GAO's performance and accountability report for fiscal year 2010.
United States. Government Accountability Office.
core  

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

Advanced Science, EarlyView.
PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan, Hong‐feng Zheng, Mu‐chen Li, Jia‐lin Zhou, Hang‐biao Zhang, Dong‐hao Lyu, Yi‐fan Tang, Tian‐yue Yang, Yi‐fan Liu, Zi‐chang Liu, Wen‐jie Ma, Yuan‐bo Zong, Jian‐gui Liu, Zi‐xuan Gong, Hao Zhang, Ke‐qin Dong, Wang Zhou, Jian‐qin Ye, Xin‐gang Cui   +18 more
wiley   +1 more source

Fiscal Year 2007 Performance and Accountability Report

, 2007
Other written product issued by the Government Accountability Office with an abstract that begins "Presented is GAO's performance and accountability report for fiscal year 2007.
United States. Government Accountability Office.
core  

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Paro nacional en Colombia: espiral de la resistencia civil noviolenta, medios de comunicación y mecanismos de impunidad

Revista de Cultura de Paz, 2021
Desde el 28 de abril hasta finales de julio, Colombia ha sido atravesada por una movilización de carácter nacional que involucra a todos los sectores sociales.
Pietro Ameglio Patella, Gabriela Monserrat Espejo Pinzón, Isabella Ariza   +2 more
doaj  

Putting the "Account'' into Cloud Accountability

Proceedings of the 9th International Conference on Cloud Computing and Services Science, 2019
Security concerns are often cited as the most prominent reason for not using cloud computing, but customers of cloud users, especially end-users, frequently do not understand the need to control access to personal information. On the other hand, some users might understand the risk, and yet have inadequate means to address it.
Jaatun, Martin Gilje, Pearson, Siani
openaire   +2 more sources

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

COMMON VIOLATIONS UNDER THE MOSCOW GOVERNMENT PROCUREMENT: THE PROBLEMS OF DETECTION AND CLASSIFICATION

Статистика и экономика, 2016
Methodological problems of violations detection under the Moscow government procurement are expounded. The great attention is paid to a qualification of these violations in compliance with the requirements of the Code of Administrative Offences of the ...
Alla V. Trofimovskaya, Maxim V. Fatin
doaj   +1 more source

Performance and Accountability Report Fiscal Year 2012 [PDF]

, 2011
Other written product issued by the Government Accountability Office with an abstract that begins "Presented is GAO's Performance and Accountability Report for fiscal year 2012.
United States. Government Accountability Office.
core