Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
VII. An account of the strata met with in digging for marle, and of horns found under ground in Ireland; in a letter from Mr. James Kelly to the Right Honourable Edward Southwell, Esq; [PDF]
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Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Accounting for the gross ecosystem product (GEP) of forests in nature reserves-taking the Taishan Scenic and Historic Spot as an example. [PDF]
PLoS OneXu C, Zhao T, Shao Y, Li X, Yan G.
europepmc +1 more source
XXIII. An account of a red coral from the East-Indies, of a very singular kind: In a letter from Mr. John Ellis, F. R. S. to Mr. Peter Collinson, F. R. S [PDF]
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Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Optimization study of intelligent accounting manager system modules in adaptive behavioral pattern learning and simulation. [PDF]
PeerJ Comput SciWang Y, Qin R, Mansoor M.
europepmc +1 more source
XXXVI. An account of the observations made on the transit of Venus, June 6, 1761, in the Island of St. Helena: In a letter to the Right Honourable George Earl of Macclesfield, President of the Royal Society, from the Rev. Nevil Maskelyne, M. A. and F. R. S [PDF]
Nevil Maskelyne, Nevil Maskelyne
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Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source