Results 241 to 250 of about 11,522,954 (312)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Temporal Trends in Type 2 Diabetes Burden and Care Outcomes in Taiwan From 2012 to 2021: Nationwide Population-Based Cohort Study. [PDF]

JMIR Public Health Surveill
Lin MY, Wu YL, Wu H, Hsu CC, iH3 Research Group.   +4 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Voluntary disclosure, banking stability, and AI-augmented forensic accounting: an exploratory econometric and machine-learning study of Palestinian banks. [PDF]

Front Big Data
Razia BS, Jadallah NI, Zureigat Q, Khamis R, Awwad BS.   +4 more
europepmc   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

Association between uncertainty regarding malignant risk and anxiety in patients with pulmonary nodules: a serial mediation analysis of illness perception and rumination. [PDF]

Front Psychiatry
Wu S, Liu M, Yi S, Wang R, Song Z, Xie F, Chen W, Qu H, Huang Y.   +8 more
europepmc   +1 more source

Smoking status and attitudes toward tobacco control among students in a vocational school in Lanzhou, China: A cross-sectional study. [PDF]

Tob Prev Cessat
Sun L, Zhao J, Zhang H, Wang L.
europepmc   +1 more source

Preventive effect of goshajinkigan on paclitaxel-induced peripheral neuropathy: an open-label, randomized phase II study (OLCSG2101). [PDF]

Oncologist
Tanaka T, Makimoto G, Nakamura N, Kato Y, Oze I, Yokoyama T, Kuyama S, Senoo S, Inoue K, Ichikawa H, Maeda Y, Togashi Y, Hotta K.   +12 more
europepmc   +1 more source