Results 151 to 160 of about 1,555,346 (303)

A Variational Formulation for Irreversible Thermodynamics with Path Dependence. [PDF]

Entropy (Basel)
Ren H.
europepmc   +1 more source

A Sectoral Analysis of Italy's Development: 1861 -2010 [PDF]

Italy’s economic growth over its 150 years of unified history did not occur at a steady pace nor was it balanced across sectors. Relying on an entirely new input (labour and capital) database by us built and presented in the Appendix, together with new ...
Broadberry, Stephen, Giordano, Claire, Zollino, Francesco   +2 more
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Predictions from early adolescent interpersonal aggression to accelerated aging in adulthood: Relational and biological mechanisms of linkage. [PDF]

Health Psychol
Allen JP, Costello MA, Hunt GL, Uchino BN, Sugden K.   +4 more
europepmc   +1 more source

Writing masters and accountants in England – a study of occupation, status and ambition in the early modern period [PDF]

The purpose of this paper is to address the lack of knowledge of the accounting occupational group in England prior to the formation of professional accounting bodies.
John Richard Edwards
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A Path-Specific Effect Approach to Mediation Analysis With Time-Varying Mediators and Time-to-Event Outcomes Accounting for Competing Risks. [PDF]

Stat Med
Domingo-Relloso A, Zhang Y, Wang Z, Suchy-Dicey AM, Buchwald DS, Navas-Acien A, Schwartz J, Berhane K, Coull BA, Valeri L.   +9 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Influence of recurrence risk perception on depressive mood in first-time stroke patients and the mediating effect of coping styles and perceived discrimination. [PDF]

Sci Rep
Wang H, Zhu D, Yan Z, Zhao J, Zhu R, Sun Y, Zhang P.   +6 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source