Results 231 to 240 of about 579,964 (385)

Evaluation of CYP2C19 Clinical Decision Support Alerts to Guide P2Y12 Inhibitor Prescribing

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
P2Y12 inhibitor selection involves numerous factors, including CYP2C19 genetics, since evidence demonstrates reduced clopidogrel efficacy in patients with decreased or no function CYP2C19 variants. In 2020, Indiana University health embedded interruptive clinical decision support (CDS) alerts in the electronic health record (EHR) to recommend ...
Ashley N. Springer   +14 more
wiley   +1 more source

Progress in Pharmacogenomics Implementation in the United States: Barrier Erosion and Remaining Challenges

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Barriers to incorporating pharmacogenetics into routine clinical practice in the United States are well documented. Initial surveys by the Clinical Pharmacogenetics Implementation Consortium (CPIC) in 2009 and 2010 identified barriers across four key domains that have hindered the widespread adoption of clinical pharmacogenetic testing.
D. Max Smith   +18 more
wiley   +1 more source

Pharmacogenetic Implementation Studies—Lessons Learned From the PREPARE Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The Ubiquitous Pharmacogenomics consortium (www.upgx.eu) has recently completed and published the Preemptive Pharmacogenomic Testing for Preventing Adverse Drug Reactions (PREPARE) study on the implementation of panel‐based pharmacogenetic testing. PREPARE has provided interesting lessons for the design, execution, and interpretation of future clinical
Henk‐Jan Guchelaar   +37 more
wiley   +1 more source

Sustainability Standards and Decertification: A Bayesian Analysis of SA8000

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Social Accountability 8000 (SA8000) is widely recognized as the leading certification‐based standard for social sustainability. The common assumption is that the number of certified companies increases steadily over time. However, this prevailing narrative lacks empirical support owing to the absence of comprehensive studies on SA8000 ...
Teresa Turzo   +3 more
wiley   +1 more source

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