Results 51 to 60 of about 609 (248)
Jet X-Ray Properties of EXO 1846-031 During Its 2019 Outburst
UniverseThe Galactic X-ray transient EXO 1846-031 was first discovered during an outburst in 1985 by the EXOSAT mission. The source remained in a quiescent state for nearly 34 years after the first outburst. The source started its second outburst on 23 July 2019.
Riya Bhowmick +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Space-Based Photometry of Binary Stars: From Voyager to TESS
Universe, 2021 Binary stars are crucial laboratories for stellar physics, so have been photometric targets for space missions beginning with the very first orbiting telescope (OAO-2) launched in 1968.
John Southworth
doaj +1 more source
Eclipse Mapping of Accretion Discs [PDF]
, 2007 The eclipse mapping method is an inversion technique that makes use of the information contained in eclipse light curves to probe the structure, the spectrum and the time evolution of accretion discs. In this review I present the basics of the method and discuss its different implementations.
openaire +2 more sources
Massive star formation by accretion [PDF]
Astronomy & Astrophysics, 2015 Massive stars likely form by accretion and the evolutionary track of an accreting forming star corresponds to what is called the birthline in the HR diagram. The shape of this birthline is quite sensitive to the evolution of the entropy in the accreting star.
Haemmerlé Lionel +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Bending instabilities in magnetized accretion discs [PDF]
Monthly Notices of the Royal Astronomical Society, 1997 We study the global bending modes of a thin annular disc subject to both an internally generated magnetic field and a magnetic field due to a dipole embedded in the central star with axis aligned with the disc rotation axis. When there is a significant inner region of the disc corotating with the star, we find spectra of unstable bending modes.
Agapitou, V, Papaloizou, J, Terquem, C
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Virial Factor and Biases in Single Epoch Black Hole Mass Determinations
Frontiers in Astronomy and Space Sciences, 2018 Accurately determining the masses of supermassive black holes is crucial to understand their evolution and the establishment of their relationship with their host galaxy properties.
Julián E. Mejía-Restrepo +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source